Sonoporation: Mechanistic insights and ongoing challenges for gene transfer

被引：164
作者：
Delalande, Anthony [1 ]
Kotopoulis, Spiros [2 ]
Postema, Michiel [2 ]
Midoux, Patrick [1 ]
Pichon, Chantal [1 ]
机构：
[1] CNRS, Ctr Biophys Mol, Orleans, France
[2] Univ Bergen, Dept Phys & Technol, Bergen, Norway
来源：
GENE | 2013年 / 525卷 / 02期
关键词：
Ultrasound; Microbubbles; Physical gene delivery method; Gene therapy; ULTRASOUND-EXPOSED MICROBUBBLES; DRUG-DELIVERY; TARGETED DELIVERY; PLASMID DNA; IN-VIVO; THERAPEUTIC APPLICATIONS; MEMBRANE DISRUPTION; FOCUSED ULTRASOUND; LIPOSOMAL BUBBLES; ENDOTHELIAL-CELLS;
D O I：
10.1016/j.gene.2013.03.095
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Microbubbles first developed as ultrasound contrast agents have been used to assist ultrasound for cellular drug and gene delivery. Their oscillation behavior during ultrasound exposure leads to transient membrane permeability of surrounding cells, facilitating targeted local delivery. The increased cell uptake of extracellular compounds by ultrasound in the presence of microbubbles is attributed to a phenomenon called sonoporation. In this review, we summarize current state of the art concerning microbubble-cell interactions and cellular effects leading to sonoporation and its application for gene delivery. Optimization of sonoporation protocol and composition of microbubbles for gene delivery are discussed. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：191 / 199
页数：9
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