Oxidative stress early in pregnancy and pregnancy outcome

被引：117
|
作者：
Stein, T. Peter [1 ]
Scholl, Theresa O. [2 ]
Schluter, Margaret D.
Leskiw, Maria J.
Chen, Xinhua [2 ]
Spur, Bernd W. [3 ]
Rodriguez, Ana [3 ]
机构：
[1] Univ Med & Dent New Jersey, Sch Osteopath Med, Dept Surg, Ctr Sci, Stratford, NJ 08084 USA
[2] Univ Med & Dent New Jersey, Sch Osteopath Med, Dept Obstet & Gynecol, Stratford, NJ 08084 USA
[3] Univ Med & Dent New Jersey, Sch Osteopath Med, Dept Cell Biol, Stratford, NJ 08084 USA
来源：
FREE RADICAL RESEARCH | 2008年 / 42卷 / 10期
关键词：
Oxidative stress; pregnancy; 8-hydroxy-2-deoxyguanosine; isoprostane; SOD; GPx; dietary antioxidants;
D O I：
10.1080/10715760802510069
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The objectives of this study were to determine whether oxidative stress early in pregnancy influenced pregnancy outcome. A combination of assays were used for exogenous and endogenous anti-oxidants together with two well accepted biomarkers for oxidative stress, the urinary excretion of 8-iso-PGF2 (a biomarker marker for lipid oxidation, n=508) and 8-oxo-7,8 dihydro-2 deoxyguanosine (8-OHdG, a biomarker for DNA oxidation, n=487). The two biomarkers tracked different pregnancy outcomes. Isoprostanes were associated with an increased risk of pre-eclampsia and a decreased proportion of female births. In contrast, 8-OHdG tracked lower infant birthweight and shortened gestation duration. Birth defects were associated with low levels of 8-OHdG.
引用
收藏
页码：841 / 848
页数：8
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