Oxidative stress early in pregnancy and pregnancy outcome

被引：120

作者：

Stein, T. Peter ^{[1
]}

Scholl, Theresa O. ^{[2
]}

Schluter, Margaret D.

Leskiw, Maria J.

Chen, Xinhua ^{[2
]}

Spur, Bernd W. ^{[3
]}

Rodriguez, Ana ^{[3
]}

机构：

[1] Univ Med & Dent New Jersey, Sch Osteopath Med, Dept Surg, Ctr Sci, Stratford, NJ 08084 USA

[2] Univ Med & Dent New Jersey, Sch Osteopath Med, Dept Obstet & Gynecol, Stratford, NJ 08084 USA

[3] Univ Med & Dent New Jersey, Sch Osteopath Med, Dept Cell Biol, Stratford, NJ 08084 USA

来源：

FREE RADICAL RESEARCH | 2008年 / 42卷 / 10期

关键词：

Oxidative stress; pregnancy; 8-hydroxy-2-deoxyguanosine; isoprostane; SOD; GPx; dietary antioxidants;

D O I：

10.1080/10715760802510069

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The objectives of this study were to determine whether oxidative stress early in pregnancy influenced pregnancy outcome. A combination of assays were used for exogenous and endogenous anti-oxidants together with two well accepted biomarkers for oxidative stress, the urinary excretion of 8-iso-PGF2 (a biomarker marker for lipid oxidation, n=508) and 8-oxo-7,8 dihydro-2 deoxyguanosine (8-OHdG, a biomarker for DNA oxidation, n=487). The two biomarkers tracked different pregnancy outcomes. Isoprostanes were associated with an increased risk of pre-eclampsia and a decreased proportion of female births. In contrast, 8-OHdG tracked lower infant birthweight and shortened gestation duration. Birth defects were associated with low levels of 8-OHdG.

引用

页码：841 / 848

页数：8

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