ERM proteins and NF2 tumor suppressor: the Yin and Yang of cortical actin organization and cell growth signaling

被引：163
作者：
Gautreau, A [1 ]
Louvard, D [1 ]
Arpin, M [1 ]
机构：
[1] Inst Curie, CNRS, UMR 144, F-75248 Paris 05, France
来源：
CURRENT OPINION IN CELL BIOLOGY | 2002年 / 14卷 / 01期
关键词：
D O I：
10.1016/S0955-0674(01)00300-3
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The ERM (ezrin, radixin and moesin) family of proteins are linkers that tether actin microfilaments to the plasma membrane, Merlin, the NF2 tumor suppressor gene product, is highly homologous to ERM proteins, In ERM proteins and merlin, interdomain binding promotes auto-inhibition and homo-oligomerization or hetero-oligomerization. Recent studies have revealed that ERM proteins transduce growth signals, and have shed new light on how merlin links cell growth to the cytoskeleton.
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页码：104 / 109
页数：6
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