Chemical Characterization of Essential Oils from Drimys angustifolia Miers (Winteraceae) and Antibacterial Activity of their Major Compounds

被引：21

作者：

Santos, Thalita G. ^{[1
]}

Dognini, Jocinei ^{[1
]}

Begnini, Ieda M. ^{[1
]}

Rebelo, Ricardo A. ^{[1
]}

Verdi, Marcio ^{[2
]}

de Gasper, Andre L. ^{[3
]}

Dalmarco, Eduardo M. ^{[4
]}

机构：

[1] Univ Reg Blumenau FURB, Dept Quim, BR-89012900 Blumenau, SC, Brazil

[2] Univ Fed Rio Grande do Sul, Dept Bot, BR-91501970 Porto Alegre, RS, Brazil

[3] Univ Reg Blumenau FURB, Herbarium Dr Roberto Miguel Klein, Dept Ciencias Nat, BR-89012900 Blumenau, SC, Brazil

[4] Univ Fed Santa Catarina, Dept Anal Clin, BR-88040970 Florianopolis, SC, Brazil

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2013年 / 24卷 / 01期

关键词：

Drimys angustifolia; essential oils; drimenol; bicyclogermacrene; antibacterial activity; BRASILIENSIS MIERS; ANTIMICROBIAL ACTIVITY; BIOLOGICAL-ACTIVITY; DRIMENOL; LEAVES; POPULATIONS; BARKS;

D O I：

10.1590/S0103-50532013000100020

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Essential oils have been extensively studied in recent years as a natural source of new antimicrobial agents. In this work, essential oils of leaf and branch from Drimys angustifolia growing in Southern Brazil were obtained by hydrodistillation and analyzed by gas chromatographies with flame ionization detector (GC-FID) and with mass spectrometer (GC-MS). Drimenol and bicyclogermacrene were isolated by column chromatography from branch and leaf essential oils, respectively. Oils, isolated compounds and combinations of them were assayed against Gram-(+) and Gram-(-) bacteria. The oils showed to be more active against Bacillus cereus, with minimum inhibitory concentration (MIC) 125 and 250 mu g mL(-1) for branch and leaf oils, respectively, strongly inhibiting bacterial growth. Bicyclogermacrene was more active then drimenol, providing a MIC value of 167 mu g mL(-1) against B. cereus. Synergism was not observed in any of the combinations tested.

引用

页码：164 / +

页数：11

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