Lahorenoic Acids A-C, ortho-Dialkyl-Substituted Aromatic Acids from the Biocontrol Strain Pseudomonas aurantiaca PB-St2

被引：74

作者：

Mehnaz, Samina ^{[1
]}

Saleem, Rahman Shah Zaib ^{[2
]}

Yameen, Basit ^{[2
]}

Pianet, Isabelle ^{[3
]}

Schnakenburg, Gregor ^{[4
]}

Pietraszkiewicz, Halina ^{[5
]}

Valeriote, Fred ^{[5
]}

Josten, Michaele ^{[6
]}

Sahl, Hans-Georg ^{[6
]}

Franzblau, Scott G. ^{[7
]}

Gross, Harald ^{[8
]}

机构：

[1] Forman Christian Coll Univ, Dept Biol Sci, Lahore 54600, Pakistan

[2] Lahore Univ Management Sci, Sch Sci & Engn, Dept Chem, Lahore 54792, Pakistan

[3] Univ Bordeaux 1, CNRS, UMR 5255, CESAMO ISM, F-33405 Talence, France

[4] Univ Bonn, Inst Organ Chem, D-53121 Bonn, Germany

[5] Henry Ford Hlth Syst, Detroit, MI 48202 USA

[6] Univ Bonn, Pharmaceut Microbiol Unit, Inst Med Microbiol Immunol & Parasitol, D-53115 Bonn, Germany

[7] Univ Illinois, Inst TB Res, Chicago, IL 60612 USA

[8] Univ Tubingen, Inst Pharmaceut Biol, D-72076 Tubingen, Germany

来源：

JOURNAL OF NATURAL PRODUCTS | 2013年 / 76卷 / 02期

关键词：

BIOLOGICAL-CONTROL; CARBOXYLIC-ACIDS; ROOT-ROT; METABOLITES; FLUORESCENS; DIKETOPIPERAZINES; PHENAZINE; IDENTIFICATION; LIPOPEPTIDES; ANTIBIOTICS;

D O I：

10.1021/np3005166

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new aromatic acids, named lahorenoic acids A (1), B (2), and C (3), have been isolated along with the known compounds phenazine-1-carboxylic acid (4), 2-hydroxyphenazine-1-carboxylic acid (5), 2-hydroxyphenazine (6), 2,8-dihydroxyphenazine (7), cyclo-Pro-Tyr (8), cyclo-Pro-Val (9), cyclo-Pro-Met (10), and WLIP (11) and characterized from the biocontrol strain Pseudomonas aurantiaca PB-St2. The structures of these compounds were deduced by 1D and 2D NMR spectroscopic and mass spectral data interpretation. Compounds 2, 4, and 7 showed moderate antibacterial activity against mycobacteria and other Gram-positive bacteria, while 4 was also found to exhibit cytotoxic and antifungal properties.

引用

页码：135 / 141

页数：7

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