Two new dihydroisocoumarins from the endophytic fungus Aspergillus sp collected from the south china sea

被引：54

作者：

Li, Shangde ^{[1
]}

Wei, Meiyan ^{[1
]}

Chen, Guangying ^{[2
]}

Lin, Yongcheng ^{[3
]}

机构：

[1] Guangdong Med Coll, Sch Pharm, Dongguan 523808, Peoples R China

[2] Hainan Normal Univ, Minist Educ, Key Lab Trop Med Plant Chem, Haikou 571158, Peoples R China

[3] Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2012年 / 48卷 / 03期

关键词：

dihydroisocoumarin; endophytic fungus; structure elucidation; antibacterial activity; MARINE NATURAL-PRODUCTS;

D O I：

10.1007/s10600-012-0254-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new dihydroisocoumarin derivatives, aspergillumarins A and B (1 and 2), were isolated from the culture broth of a marine-derived fungus Aspergillus sp., which was isolated from the fresh leaf of the mangrove tree Bruguiera gymnorrhiza collected from the South China Sea. The structures of compounds 1 and 2 were established by comprehensive analysis of the spectral data, especially 2D NMR spectra results. Compounds 1 and 2 showed weak antibacterial activity against Staphylococcus aureus and Bacillus subtilis at a concentration of 50 mu g/mL.

引用

页码：371 / 373

页数：3

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