The Hippo pathway in organ development, homeostasis, and regeneration

被引：171

作者：

Fu, Vivian

Plouffe, Steven W.

Guan, Kun-Liang ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2017年 / 49卷

基金：

美国国家卫生研究院;

关键词：

STEM-CELL PROLIFERATION; SIGNALING PATHWAY; INTESTINAL REGENERATION; NEURAL CREST; EFFECTOR YAP; CARDIOMYOCYTE PROLIFERATION; HEART REGENERATION; TISSUE HOMEOSTASIS; SIZE-CONTROL; DIFFERENTIATION;

D O I：

10.1016/j.ceb.2017.12.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Hippo pathway is a universal governor of organ size, tissue homeostasis, and regeneration. A growing body of work has advanced our understanding of Hippo pathway regulation of cell proliferation, differentiation, and spatial patterning not only in organ development but also upon injury-induced regeneration. The pathway's central role in stem cell biology thus implicates its potential for therapeutic manipulation in mammalian organ regeneration. In this review, we survey recent literature linking the Hippo pathway to the development, homeostasis, and regeneration of various organs, including Hippo-independent roles for YAP, defined here as YAP functions that are not regulated by the Hippo pathway kinases LATS1/2.

引用

页码：99 / 107

页数：9

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