Increased adrenocortical response to adrenocorticotropic hormone (ACTH) in sport horses with equine glandular gastric disease (EGGD)

被引:37
作者
Scheidegger, M. D. [1 ,2 ]
Gerber, V. [1 ,2 ]
Bruckmaier, R. M. [3 ]
van der Kolk, J. H. [1 ,2 ]
Burger, D. [1 ,2 ]
Ramseyer, A. [1 ,2 ]
机构
[1] Agroscope, Vetsuisse Fac, Swiss Inst Equine Med ISME, Langgassstr 124,Postfach 8466, CH-3001 Bern, Switzerland
[2] Univ Bern, Langgassstr 124,Postfach 8466, CH-3001 Bern, Switzerland
[3] Univ Bern, Vetsuisse Fac, Vet Physiol, Bremgartenstr 109a, CH-3001 Bern, Switzerland
关键词
ACTH; Adrenal function; Gastric ulcerations; Horses; Stress; ENDURANCE HORSES; STIMULATION TEST; ULCER SYNDROME; ADULT HORSES; RISK-FACTORS; PREVALENCE; STRESS; CONFINEMENT; RACEHORSES; STOMACH;
D O I
10.1016/j.tvjl.2017.09.002
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
This study tested the hypothesis that adrenocortical function would be altered in horses with equine gastric ulcer syndrome (EGUS). Twenty-six sport horses competing at national or international levels in eventing (n =15) or endurance (n =11) were subjected to a gastroscopic examination and an adrenocorticotropic hormone (ACTH) stimulation test. Salivary cortisol concentrations were measured before (baseline) and after (30, 60, 90,120 and 150 min) IV ACTH injection (1 mu g/kg bodyweight). Within EGUS, two distinct diseases, equine squamous gastric disease (ESGD) and equine glandular gastric disease (EGGD), can be distinguished. ESGD was diagnosed in 8/11 (73%; 95% confidence intervals [95%Cl], 43-92%) endurance horses and 5/ 15 (33%; 95% CI, 14-58%) eventing horses. EGGD was observed in 9/11 (82%; 95% CI, 53-96%) endurance horses and 9/15 (60%; 95% CI, 35-81%) eventing horses. The presence or severity of ESGD was unrelated to the presence or severity of EGGD. ACTH stimulation induced a larger increase in cortisol concentration in horses with moderate EGGD than in horses with mild EGGD. Cortisol concentration during the entire sampling period (total increase in cortisol concentration during the entire sampling period [dAUC], 31.1 6.4 ng/mL) and the highest measured concentration at a single time point (maximal increase in cortisol concentration [dMAX], 10.3 +/- 2.3 ng/mL) were increased (P=0.005 and P=0.038, respectively), indicating that horses with glandular gastric disease exhibited increased adrenocortical responses to ACTH stimulation. These results suggest that EGGD might be associated with an enhanced adrenocortical sensitivity. Further investigations are warranted to confirm the association between adrenocortical sensitivity and EGGD and to elucidate the pathophysiological mechanisms involved. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码:7 / 12
页数:6
相关论文
共 38 条
[21]   Exploration of the hypothalamic-pituitary-adrenal function as a tool to evaluate animal welfare [J].
Mormede, Pierre ;
Andanson, Stephane ;
Auperin, Benoit ;
Beerda, Bonne ;
Guemene, Daniel ;
Malmkvist, Jens ;
Manteca, Xavier ;
Manteuffel, Gerhard ;
Prunet, Patrick ;
van Reenen, Cornelis G. ;
Richard, Sabine ;
Veissier, Isabelle .
PHYSIOLOGY & BEHAVIOR, 2007, 92 (03) :317-339
[22]  
Murray MJ, 1996, AM J VET RES, V57, P1599
[23]  
Nagat S., 2010, EQUINE VET J, V31, P570
[24]   Endoscopic findings of the stomach in pleasure horses in Poland [J].
Niedzwiedz, Artur ;
Kubiak, Krzysztof ;
Nicpon, Jozef .
ACTA VETERINARIA SCANDINAVICA, 2013, 55 :45
[25]   Prevalence of gastric ulcers in endurance horses - a preliminary report [J].
Nieto, JE ;
Snyder, JR ;
Beldomenico, P ;
Aleman, M ;
Kerr, JW ;
Spier, SJ .
VETERINARY JOURNAL, 2004, 167 (01) :33-37
[26]   Comparison between blood serum and salivary cortisol concentrations in horses using an adrenocorticotropic hormone challenge [J].
Peeters, M. ;
Sulon, J. ;
Beckers, J. -F. ;
Ledoux, D. ;
Vandenheede, M. .
EQUINE VETERINARY JOURNAL, 2011, 43 (04) :487-493
[27]   Repeatability of the ACTH stimulation test as reflected by salivary cortisol response in healthy horses [J].
Scheidegger, M. D. ;
Gerber, V. ;
Ramseyer, A. ;
Schupbach-Regula, G. ;
Bruckmaier, R. M. ;
van der Kolk, J. H. .
DOMESTIC ANIMAL ENDOCRINOLOGY, 2016, 57 :43-47
[28]   Cortisol release and heart rate variability in horses during road transport [J].
Schmidt, Alice ;
Moestl, Erich ;
Wehnert, Christiane ;
Aurich, Joerg ;
Mueller, Juergen ;
Aurich, Christine .
HORMONES AND BEHAVIOR, 2010, 57 (02) :209-215
[29]  
Selye H., 1978, STRESS LIFE, P15
[30]  
Stewart AJ, 2011, JAVMA-J AM VET MED A, V239, P834, DOI 10.2460/javma.239.6.834