Recent progress in structure-based anti-influenza drug design

被引：71

作者：

Du, Juan ^{[1
,3
]}

Cross, Timothy A. ^{[2
,3
,4
]}

Zhou, Huan-Xiang ^{[1
,3
]}

机构：

[1] Florida State Univ, Dept Phys, Tallahassee, FL 32306 USA

[2] Florida State Univ, Dept Chem & Biochem, Tallahassee, FL 32306 USA

[3] Florida State Univ, Inst Mol Biophys, Tallahassee, FL 32306 USA

[4] Natl High Magnet Field Lab, Tallahassee, FL 32310 USA

来源：

DRUG DISCOVERY TODAY | 2012年 / 17卷 / 19-20期

基金：

美国国家卫生研究院;

关键词：

INFLUENZA-A VIRUS; M2 PROTON CHANNEL; RECEPTOR-BINDING PROPERTIES; NEURAMINIDASE INHIBITORS; SIALIC-ACID; MATRIX PROTEIN; HIGHLY POTENT; ION-CHANNEL; RNA-BINDING; M1; PROTEIN;

D O I：

10.1016/j.drudis.2012.06.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Seasonal and pandemic influenza have caused high morbidity and mortality worldwide. Recent emergence of influenza A H5N1 and H1N1 strains has heightened concern, especially as a result of their drug resistance. The life cycle of influenza viruses has been well studied and nearly all the viral proteins are becoming potential therapeutic targets. In this review, we present an overview of recent progress in structure-based anti-influenza drug design, paying close attention to the increasing role of computation and strategies for overcoming drug resistance.

引用

页码：1111 / 1120

页数：10

共 115 条

[1] Crystal structure of the M1 protein-binding domain of the influenza A virus nuclear export protein (NEP/NS2) [J].

Akarsu, H ;

Burmeister, WP ;

Petosa, C ;

Petit, I ;

Müller, CW ;

Ruigrok, RWH ;

Baudin, F .

EMBO JOURNAL, 2003, 22 (18) :4646-4655

[2] Structure-based design of NS2 mutants for attenuated influenza A virus vaccines [J].

Akarsu, Hatice ;

Iwatsuki-Horimoto, Kiyoko ;

Noda, Takeshi ;

Kawakami, Eiryo ;

Katsura, Hiroaki ;

Baudin, Florence ;

Horimoto, Taisuke ;

Kawaoka, Yoshihiro .

VIRUS RESEARCH, 2011, 155 (01) :240-248

[3] Remarkable loop flexibility in avian influenza N1 and its implications for antiviral drug design [J].

Amaro, Rommie E. ;

Minh, David D. L. ;

Cheng, Lily S. ;

Lindstrom, William M., Jr. ;

Olson, Arthur J. ;

Lin, Jung-Hsin ;

Li, Wilfred W. ;

McCammon, J. Andrew .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (25) :7764-+

[4] Mechanism of 150-cavity formation in influenza neuraminidase [J].

Amaro, Rommie E. ;

Swift, Robert V. ;

Votapka, Lane ;

Li, Wilfred W. ;

Walker, Ross C. ;

Bush, Robin M. .

NATURE COMMUNICATIONS, 2011, 2

[5] A Novel Small-Molecule Inhibitor of the Avian Influenza H5N1 Virus Determined through Computational Screening against the Neuraminidase [J].

An, Jianghong ;

Lee, Davy C. W. ;

Law, Anna H. Y. ;

Yang, Cindy L. H. ;

Poon, Leo L. M. ;

Lau, Allan S. Y. ;

Jones, Steven J. M. .

JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (09) :2667-2672

[6] Combined results from solution studies on intact influenza virus M1 protein and from a new crystal form of its N-terminal domain show that M1 is an elongated monomer [J].

Arzt, S ;

Baudin, F ;

Barge, A ;

Timmins, P ;

Burmeister, WP ;

Ruigrok, RWH .

VIROLOGY, 2001, 279 (02) :439-446

[7] BCX-1812 (RWJ-270201): Discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design [J].

Babu, YS ;

Chand, P ;

Bantia, S ;

Kotian, P ;

Dehghani, A ;

El-Kattan, Y ;

Lin, TH ;

Hutchison, TL ;

Elliott, AJ ;

Parker, CD ;

Ananth, SL ;

Horn, LL ;

Laver, GW ;

Montgomery, JA .

JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (19) :3482-3486

[8] Design and Pharmacological Characterization of Inhibitors of Amantadine-Resistant Mutants of the M2 Ion Channel of Influenza A Virus [J].

Balannik, Victoria ;

Wang, Jun ;

Ohigashi, Yuki ;

Jing, Xianghong ;

Magavern, Emma ;

Lamb, Robert A. ;

DeGrado, William F. ;

Pinto, Lawrence H. .

BIOCHEMISTRY, 2009, 48 (50) :11872-11882

[9] Novel Influenza Virus NS1 Antagonists Block Replication and Restore Innate Immune Function [J].

Basu, Dipanwita ;

Walkiewicz, Marcin P. ;

Frieman, Matthew ;

Baric, Ralph S. ;

Auble, David T. ;

Engel, Daniel A. .

JOURNAL OF VIROLOGY, 2009, 83 (04) :1881-1891

[10] INHIBITION OF THE FUSION-INDUCING CONFORMATIONAL CHANGE OF INFLUENZA HEMAGGLUTININ BY BENZOQUINONES AND HYDROQUINONES [J].

BODIAN, DL ;

YAMASAKI, RB ;

BUSWELL, RL ;

STEARNS, JF ;

WHITE, JM ;

KUNTZ, ID .

BIOCHEMISTRY, 1993, 32 (12) :2967-2978

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