Prognostic Influence of Tumor Stroma on Breast Cancer Subtypes

被引：22

作者：

Cid, Sandra ^{[1
]}

Eiro, Noemi ^{[1
]}

Fernandez, Berta ^{[2
]}

Sanchez, Rosario ^{[3
]}

Andicoechea, Alejandro ^{[3
]}

Fernandez-Muniz, Pablo Ignacio ^{[4
]}

Gonzalez, Luis O. ^{[5
]}

Vizoso, Francisco J. ^{[1
,3
]}

机构：

[1] Fdn Hosp Jove, Unidad Invest, Avda Eduardo Castro 161, Gijon 33920, Asturias, Spain

[2] Hosp Cabuenes, Serv Cirugia, Gijon, Spain

[3] Fdn Hosp Jove, Serv Cirugia, Gijon, Spain

[4] Hosp Univ Cent Asturias, Oviedo, Spain

[5] Fdn Hosp Jove, Serv Anat Patol, Gijon, Spain

来源：

CLINICAL BREAST CANCER | 2018年 / 18卷 / 01期

关键词：

Cancer-associated fibroblasts; Intratumoral inflammatory cells; MMPs; Molecular subtype; TIMPs; MONONUCLEAR INFLAMMATORY CELLS; GENE-EXPRESSION PROFILES; MATRIX METALLOPROTEINASES; MOLECULAR PORTRAITS; AMERICAN-SOCIETY; TISSUE INHIBITOR; INVASIVE FRONT; CLINICAL-VALUE; GROWTH; THERAPY;

D O I：

10.1016/j.clbc.2017.08.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast tumors are categorized into 4 major subtypes to predict the prognosis, using 3 standard immunohistochemical markers. Despite these classifications, numerous patients have died of relapsed disease. We performed an immunohistochemical study with 247 tumors of patients, and we demonstrated a significant relationship between the expression of matrix metalloproteinases/tissue inhibitors of metalloproteinases by tumor stroma and relapse-free survival, in order to improve the prognostic evaluation of all breast cancer subtypes. Introduction: The objective of the present work was to evaluate the impact of the phenotype of both intratumoral mononuclear inflammatory cells (MICs) and cancer-associated fibroblast (CAFs), assessed as to their expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) on prognosis in different breast cancer subtypes. Materials and Methods: A total of 247 tumors of patients with primary ductal invasive breast cancer were categorized into 1 of 4 major subtypes, using the 3 standard immunohistochemical markers (estrogen receptor [ER], progesterone receptor [PR], and human epidermal growth factor receptor/Neu 2 [HER2] receptor status). An immunohistochemical study was performed using tissue arrays and specific antibodies against MMP-9, MMP-11, and MMP-14, and TIMP-1 and TIMP-2. Results: MMP-11 expression by MICs was significantly and strongly associated with prognosis in all breast cancer subtypes. There were other significant associations with poor prognosis in luminal A tumors: expressions of MMP-9, MMP-11, and TIMP-2 by CAFs, in luminal B tumors: MMP-14 expression by MICs and TIMP-2 expression by MICs, in HER-2-positive tumors: expression of MMP-9 by MICs, and in triple negative breast cancers: expression of TIMP-1 by MICs. Conclusion: Characterization of both tumor stromal CAFs and MICs, with regard to the expression of MMPs and TIMPs, improve the prognostic evaluation of all breast cancer (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：E123 / E133

页数：11

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