Unlocking the chromatin code by deciphering protein-DNA interactions

被引：2
|
作者：
Bensaddek, Dalila [1 ]
Lamond, Angus I. [1 ]
机构：
[1] Univ Dundee, Sch Life Sci, Discovery Ctr, Lab Quantitat Prote,Ctr Gene Regulat & Express, Dundee, Scotland
来源：
MOLECULAR SYSTEMS BIOLOGY | 2016年 / 12卷 / 11期
关键词：
MASS-SPECTROMETRY;
D O I：
10.15252/msb.20167332
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Characterizing the composition of protein complexes bound to different genomic loci is essential for advancing our mechanistic understanding of transcriptional regulation. In their recent study, Krijgsveld and colleagues (Rafiee etal, ) report ChIP-SICAP, a powerful tool for deciphering the chromatin proteome by combining chromatin immunoprecipitation, selective isolation of chromatin-associated proteins and mass spectrometry.
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页数：3
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