Sequence polymorphisms of the mitochondrial displacement loop and outcome of non-small cell lung cancer

被引：16

作者：

Ding, Cuimin ^{[2
]}

Li, Ruijuan ^{[2
]}

Wang, Ping ^{[2
]}

Fan, Haiyan ^{[1
]}

Guo, Zhanjun ^{[1
]}

机构：

[1] Hebei Med Univ, Hosp 4, Dept Gastroenterol & Hepatol, Shijiazhuang 050011, Hebei, Peoples R China

[2] Hebei Med Univ, Hosp 4, Dept Resp Med, Shijiazhuang 050011, Hebei, Peoples R China

来源：

EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2012年 / 3卷 / 05期

基金：

中国国家自然科学基金;

关键词：

displacement loop; non-small cell lung cancer; outcome; single-nucleotide polymorphism; mitochondrial DNA; OXIDATIVE STRESS; HEPATOCELLULAR-CARCINOMA; DNA MUTATIONS; PANCREATIC-CANCER; IDENTIFICATION; TRANSCRIPTION; MAINTENANCE; SURVIVAL; MODELS; REGION;

D O I：

10.3892/etm.2012.490

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Accumulation of single-nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) may be associated with disease outcome. Our team investigated the prediction power of D-loop SNPs in non-small cell lung cancer (NSCLC) outcome. In an overall multivariate analysis, allele 16390 was identified as an independent predictor for NSCLC outcome. The length of survival of patients with allele 16390A was significantly shorter than that of patients with allele 16390G (relative risk, 0.323; 95% CI, 0.109-0.951; p=0.040). The analysis of genetic polymorphisms in the mitochondrial D-loop can help identify NSCLC patient subgroups at a high risk for a poor disease outcome.

引用

页码：861 / 864

页数：4

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