Neural Substrates of Visuospatial Processing in Distinct Reference Frames: Evidence from Unilateral Spatial Neglect

被引:131
作者
Medina, Jared [1 ,3 ]
Kannan, Vijay [2 ]
Pawlak, Mikolaj A. [3 ,4 ]
Kleinman, Jonathan T. [2 ]
Newhart, Melissa [2 ]
Davis, Cameron [2 ]
Heidler-Gary, Jennifer E. [2 ]
Herskovits, Edward H. [3 ]
Hillis, Argye E. [1 ,2 ]
机构
[1] Johns Hopkins Univ, Baltimore, MD 21218 USA
[2] Johns Hopkins Med Inst, Baltimore, MD 21218 USA
[3] Univ Penn, Philadelphia, PA 19104 USA
[4] Karol Marcinkowski Univ Med Sci, Poznan, Poland
关键词
RIGHT-HEMISPHERE STROKE; HEMISPATIAL NEGLECT; MAGNETIC-RESONANCE; VISUAL NEGLECT; CENTERED NEGLECT; OBJECT RECOGNITION; SUNNYBROOK STROKE; ISCHEMIC-STROKE; PARIETAL LOBE; PERFUSION;
D O I
10.1162/jocn.2008.21160
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
There is evidence for different levels of visuospatial processing with their own frames of reference: viewer-centered, stimulus-centered, and object-centered. The neural locus of these levels can be explored by examining lesion location in subjects with unilateral spatial neglect (USN) manifest in these reference frames. Most studies regarding the neural locus of USN have treated it as a homogenous syndrome, resulting in conflicting results. In order to further explore the neural locus of visuospatial processes differentiated by frame of reference, we presented a battery of tests to 171 subjects within 48 hr after right supratentorial ischemic stroke before possible structural and/or functional reorganization. The battery included MR perfusion weighted imaging ( which shows hypoperfused regions that may be dysfunctional), diffusion weighted imaging ( which reveals areas of infarct or dense ischemia shortly after stroke onset), and tests designed to disambiguate between various types of neglect. Results were consistent with a dorsal/ventral stream distinction in egocentric/allocentric processing. We provide evidence that portions of the dorsal stream of visual processing, including the right supramarginal gyrus, are involved in spatial encoding in egocentric coordinates, whereas parts of the ventral stream ( including the posterior inferior temporal gyrus) are involved in allocentric encoding.
引用
收藏
页码:2073 / 2084
页数:12
相关论文
共 65 条
[1]  
ANDERSEN RA, 1990, J NEUROSCI, V10, P1176
[2]   EVIDENCE FOR AN INDEPENDENT STIMULUS-CENTERED SPATIAL REFERENCE FRAME FROM A CASE OF VISUAL HEMINEGLECT [J].
ARGUIN, M ;
BUB, DN .
CORTEX, 1993, 29 (02) :349-357
[3]   NEGLECT DYSGRAPHIA [J].
BAXTER, DM ;
WARRINGTON, EK .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1983, 46 (12) :1073-1078
[4]  
Beaulieu C, 1999, ANN NEUROL, V46, P568, DOI 10.1002/1531-8249(199910)46:4<568::AID-ANA4>3.0.CO
[5]  
2-R
[6]   Attention accesses multiple reference frames: Evidence from visual neglect [J].
Behrmann, M ;
Tipper, SP .
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-HUMAN PERCEPTION AND PERFORMANCE, 1999, 25 (01) :83-101
[7]   2 BASIC PROPERTIES OF SPACE REPRESENTATION IN THE BRAIN - EVIDENCE FROM UNILATERAL NEGLECT [J].
BISIACH, E ;
CAPITANI, E ;
PORTA, E .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1985, 48 (02) :141-144
[8]   HEAD POSITION SIGNALS USED BY PARIETAL NEURONS TO ENCODE LOCATIONS OF VISUAL-STIMULI [J].
BROTCHIE, PR ;
ANDERSEN, RA ;
SNYDER, LH ;
GOODMAN, SJ .
NATURE, 1995, 375 (6528) :232-235
[9]   Reference frames for spatial cognition: Different brain areas are involved in viewer-, object-, and landmark-centered judgments about object location [J].
Committeri, G ;
Galati, G ;
Paradis, AL ;
Pizzamiglio, L ;
Berthoz, A ;
LeBihan, D .
JOURNAL OF COGNITIVE NEUROSCIENCE, 2004, 16 (09) :1517-1535
[10]   CAN VISUAL NEGLECT OPERATE IN OBJECT-CENTERED COORDINATES - AN AFFIRMATIVE SINGLE-CASE STUDY [J].
DRIVER, J ;
HALLIGAN, PW .
COGNITIVE NEUROPSYCHOLOGY, 1991, 8 (06) :475-496