Impact of G protein-coupled receptor heteromers in endocrine systems

被引：16

作者：

Jonas, K. C. ^{[1
]}

Hanyaloglu, A. C. ^{[2
]}

机构：

[1] St Georges Univ London, Ctr Med & Biomed Educ, Cell Biol & Genet Res Ctr, London, England

[2] Imperial Coll London, Inst Reprod & Dev Biol, Dept Surg & Cancet, London, England

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2017年 / 449卷 / 0C期

基金：

英国生物技术与生命科学研究理事会;

关键词：

GPCR; Dimer; Oligomer; Signaling; Heteromer; RESONANCE ENERGY-TRANSFER; SINGLE-MOLECULE ANALYSIS; TIME-RESOLVED FRET; LUTEINIZING-HORMONE; HUMAN GRANULOSA; HETERODIMERIZATION; LUTROPIN; GHRELIN; REVEAL; CELLS;

D O I：

10.1016/j.mce.2017.01.030

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The fine-tuning of endocrine homeostasis is regulated by dynamic receptor mediated processes. The superfamily of G protein-coupled receptors (GPCRs) have diverse roles in the modulation of all endocrine axes, thus understanding the mechanisms underpinning their functionality is paramount for treatment of endocrinopathies. Evidence over the last 20 years has highlighted homo and heteromerization as a key mode of mediating GPCR functional diversity. This review will discuss the concept of GPCR heteromerization and its relevance to endocrine function, detailing in vitro and in vivo evidence, and exploring current and potential pharmacological strategies for specific targeting of GPCR heteromers in endocrine heath and disease. Crown Copyright (C) 2017 Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：21 / 27

页数：7

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