Impact of G protein-coupled receptor heteromers in endocrine systems

被引：16

作者：

Jonas, K. C. ^{[1
]}

Hanyaloglu, A. C. ^{[2
]}

机构：

[1] St Georges Univ London, Ctr Med & Biomed Educ, Cell Biol & Genet Res Ctr, London, England

[2] Imperial Coll London, Inst Reprod & Dev Biol, Dept Surg & Cancet, London, England

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2017年 / 449卷 / 0C期

基金：

英国生物技术与生命科学研究理事会;

关键词：

GPCR; Dimer; Oligomer; Signaling; Heteromer; RESONANCE ENERGY-TRANSFER; SINGLE-MOLECULE ANALYSIS; TIME-RESOLVED FRET; LUTEINIZING-HORMONE; HUMAN GRANULOSA; HETERODIMERIZATION; LUTROPIN; GHRELIN; REVEAL; CELLS;

D O I：

10.1016/j.mce.2017.01.030

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The fine-tuning of endocrine homeostasis is regulated by dynamic receptor mediated processes. The superfamily of G protein-coupled receptors (GPCRs) have diverse roles in the modulation of all endocrine axes, thus understanding the mechanisms underpinning their functionality is paramount for treatment of endocrinopathies. Evidence over the last 20 years has highlighted homo and heteromerization as a key mode of mediating GPCR functional diversity. This review will discuss the concept of GPCR heteromerization and its relevance to endocrine function, detailing in vitro and in vivo evidence, and exploring current and potential pharmacological strategies for specific targeting of GPCR heteromers in endocrine heath and disease. Crown Copyright (C) 2017 Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：21 / 27

页数：7

共 74 条

[1] Increased AT1 receptor heterodimers in preeclampsia mediate enhanced angiotensin II responsiveness [J].

AbdAlla, S ;

Lother, H ;

el Massiery, A ;

Quitterer, U .

NATURE MEDICINE, 2001, 7 (09) :1003-1009

[2] Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors [J].

Agnes, Richard S. ;

Lee, Yeon Sun ;

Davis, Peg ;

Ma, Shou-Wu ;

Badghisi, Hamid ;

Porreca, Frank ;

Lai, Josephine ;

Hruby, Victor J. .

JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (10) :2868-2875

[3]

Akgun Eyup, 2013, Proc Natl Acad Sci U S A, V110, P11595, DOI 10.1073/pnas.1305461110

[4]

Albizu L, 2010, NAT CHEM BIOL, V6, P587, DOI [10.1038/NCHEMBIO.396, 10.1038/nchembio.396]

[5] Detection of β2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET) [J].

Angers, S ;

Salahpour, A ;

Joly, E ;

Hilairet, S ;

Chelsky, D ;

Dennis, M ;

Bouvier, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (07) :3684-3689

[6] Functional Interaction between Angiotensin II Receptor Type 1 and Chemokine (C-C Motif) Receptor 2 with Implications for Chronic Kidney Disease [J].

Ayoub, Mohammed Akli ;

Zhang, Yuan ;

Kelly, Robyn S. ;

See, Heng B. ;

Johnstone, Elizabeth K. M. ;

McCall, Elizabeth A. ;

Williams, James H. ;

Kelly, Darren J. ;

Pfleger, Kevin D. G. .

PLOS ONE, 2015, 10 (03)

[7]

Berque-Bestel Isabelle, 2008, Curr Drug Discov Technol, V5, P312, DOI 10.2174/157016308786733591

[8] Development of Selective LH Receptor Agonists by Heterodimerization with a FSH Receptor Antagonist [J].

Bonger, Kimberly M. ;

Hoogendoorn, Sascha ;

van Koppen, Chris J. ;

Timmers, C. Marco ;

van der Marel, Gijsbert A. ;

Overkleeft, Herman S. .

ACS MEDICINAL CHEMISTRY LETTERS, 2011, 2 (01) :85-89

[9] Discovery of Selective Luteinizing Hormone Receptor Agonists Using the Bivalent Ligand Method [J].

Bonger, Kimberly M. ;

van den Berg, Richard J. B. H. N. ;

Knijnenburg, Annemiek D. ;

Heitman, Laura H. ;

van Koppen, Chris J. ;

Timmers, Cornelis M. ;

Overkleeft, Herman S. ;

van der Marel, Gijsbert A. .

CHEMMEDCHEM, 2009, 4 (07) :1189-1195

[10] Single-molecule analysis of fluorescently labeled G-protein-coupled receptors reveals complexes with distinct dynamics and organization [J].

Calebiro, Davide ;

Rieken, Finn ;

Wagner, Julia ;

Sungkaworn, Titiwat ;

Zabel, Ulrike ;

Borzi, Alfio ;

Cocucci, Emanuele ;

Zuern, Alexander ;

Lohse, Martin J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (02) :743-748

← 1 2 3 4 5 6 7 8 →