When chromatin meets splicing

被引：54

作者：

Kornblihtt, Alberto R. ^{[1
,2
]}

Schor, Ignacio E. ^{[1
,2
]}

Allo, Mariano ^{[1
,2
]}

Blencowe, Benjamin J. ^{[3
]}

机构：

[1] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Fisiol & Biol Mol, LFBM, Buenos Aires, DF, Argentina

[2] Univ Buenos Aires, Fac Ciencias Exactas & Nat, CONICET, IFIByNE, Buenos Aires, DF, Argentina

[3] Univ Toronto, Ctr Cellular & Biomol Res, Toronto, ON, Canada

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2009年 / 16卷 / 09期

关键词：

TRANSCRIPTION; ORGANIZATION; RECRUITMENT; RECOGNITION;

D O I：

10.1038/nsmb0909-902

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using bioinformatics analysis of previously published global genome deep-sequencing data, two papers now show that DNA sequences associated with nucleosomes are preferentially located in exons. The correlation between nucleosome distribution and the exon-intron organization of genes may have a key role in exon recognition at the pre-mRNA level during co-transcriptional splicing, consistent with previous findings indicating chromatin-mediated regulation of alternative splicing.

引用

收藏

页码：902 / 903

页数：2

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