Protein Kinase Ca Puts the Handcuffs on Epidermal Keratinocyte Proliferation

被引：12

作者：

Bollag, Wendy B. ^{[1
,2
]}

机构：

[1] Med Coll Georgia, Dermatol Sect, Dept Med, Inst Mol Med & Genet, Augusta, GA 30912 USA

[2] Charlie Norwood VA Med Ctr, Augusta, GA USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2009年 / 129卷 / 10期

关键词：

ALPHA; DIFFERENTIATION; PHOSPHORYLATION; INFLAMMATION; HYPERPLASIA; INDUCTION; EPSILON; DELTA;

D O I：

10.1038/jid.2009.165

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

As the predominant cellular receptor for phorbol esters, protein kinase C (PKC) is assumed to play a role in epidermal carcinogenesis. Nevertheless, determining its exact role in keratinocytes has been difficult because of the existence of multiple PKC isoforms and the inherent weaknesses in methodologies used to investigate their function. In this issue, Jerome-Morais et al. describe their use of multiple in vitro, in situ, overexpression, and knockdown approaches to demonstrate that PKC alpha induces keratinocyte growth arrest.

引用

收藏

页码：2330 / 2332

页数：4

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