Expression of the Inhibitory CD200 Receptor Is Associated with Alternative Macrophage Activation

被引:96
|
作者
Koning, Nathalie [4 ]
van Eijk, Marco [2 ]
Pouwels, Walter
Brouwer, Michael S. M.
Voehringer, David [5 ]
Huitinga, Inge [3 ,4 ]
Hoek, Robert M.
Raes, Geert [6 ,7 ]
Hamann, Jorg [1 ]
机构
[1] Univ Amsterdam, Acad Med Ctr, Dept Expt Immunol, NL-1100 DE Amsterdam, Netherlands
[2] Univ Amsterdam, Acad Med Ctr, Dept Med Biochem, NL-1100 DE Amsterdam, Netherlands
[3] Netherlands Brain Bank, Amsterdam, Netherlands
[4] Acad Arts & Sci, Inst Royal Netherlands, Netherlands Inst Neurosci, Dept Neuroimmunol, Amsterdam, Netherlands
[5] Univ Munich, Inst Immunol, Dept Med, D-8000 Munich, Germany
[6] Vrije Univ Brussel, Cellular & Mol Immunol Lab, Brussels, Belgium
[7] VIB, Dept Mol & Cellular Interact, Brussels, Belgium
关键词
IL-4; Immune inhibition; Macrophage polarization; Parasite infection; Type; 2; responses; DOWN-REGULATION; FAMILY; CELLS; IMMUNITY; MANNOSE; MARKER;
D O I
10.1159/000252803
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Classical macrophage activation is inhibited by the CD200 receptor (CD200R). Here, we show that CD200R expression was specifically induced on human in vitro polarized macrophages of the alternatively activated M2a subtype, generated by incubation with IL-4 or IL-13. In mice, peritoneal M2 macrophages, elicited during infection with the parasites Taenia crassiceps or Tryponosoma brucei brucei, expressed increased CD200R levels compared to those derived from uninfected mice. However, in vitro stimulation of mouse peritoneal macrophages and T crassiceps infection in IL-4-/- and IL-4R-/- mice showed that, in contrast to humans, induction of CD200R in mice was not IL-4 or IL-13 dependent. Our data identify CD200R as a suitable marker for alternatively activated macrophages in humans and corroborate observations of distinct species- and/or site-specific mechanisms regulating macrophage polarization in mouse and man. Copyright (C) 2009 S. Karger AG, Basel
引用
收藏
页码:195 / 200
页数:6
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