A new facile synthesis of 3-amidoindole derivatives and their evaluation as potential GSK-3β inhibitors

被引：57
作者：
Pews-Davtyan, Anahit [2 ]
Tillack, Annegret [2 ]
Schmoele, Anne-Caroline [1 ]
Ortinau, Stefanie [1 ]
Frech, Moritz J. [1 ]
Rolfs, Arndt [1 ]
Beller, Matthias [2 ]
机构：
[1] Univ Rostock, Albrecht Kossel Inst Neuroregenerat, Ctr Mental Hlth Dis, D-18147 Rostock, Germany
[2] Univ Rostock, Leibniz Inst Katalyse eV, D-18059 Rostock, Germany
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 05期
关键词：
ONE-POT SYNTHESIS; INTRAMOLECULAR HYDROAMINATION; INTERMOLECULAR HYDROAMINATION; TERMINAL ALKYNES; DOMINO SYNTHESIS; CATALYTIC HYDROAMINATION; BIOLOGICAL EVALUATION; CONVENIENT SYNTHESIS; REDUCTIVE ACYLATION; SUBSTITUTED INDOLES;
D O I：
10.1039/b920861e
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
3-Amidoindoles were synthesized from commercially available arylhydrazines and propargylamines over Zn-salt mediated one pot procedure in excellent regioselectivity and up to 94% yield.
引用
收藏
页码：1149 / 1153
页数：5
相关论文
共 106 条
[1]   Use of group 4 bis(sulfonamido) complexes in the intramolecular hydroamination of alkynes and allenes [J].
Ackermann, L ;
Bergman, RG ;
Loy, RN .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (39) :11956-11963
[2]   TiCl4-catalyzed intermolecular hydroamination reactions [J].
Ackermann, L .
ORGANOMETALLICS, 2003, 22 (22) :4367-4368
[3]   Catalytic arylations with challenging substrates: From air-stable HASPO preligands to indole syntheses and C-H-bond functionalizations [J].
Ackermann, Lutz .
SYNLETT, 2007, (04) :507-526
[4]   Copper-Catalyzed N-Arylation/Hydroamin(d)ation Domino Synthesis of Indoles and its Application to the Preparation of a Chek1/KDR Kinase Inhibitor Pharmacophore [J].
Ackermann, Lutz ;
Barfuesser, Sebastian ;
Potukuchi, Harish K. .
ADVANCED SYNTHESIS & CATALYSIS, 2009, 351 (7-8) :1064-1072
[5]  
Alex K., 2008, Angew. Chem, V120, P2337
[6]   Zinc-promoted hydrohydrazination of terminal alkynes: An efficient domino synthesis of indoles [J].
Alex, Karolin ;
Tillack, Annegret ;
Schwarz, Nicolle ;
Beller, Matthias .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, 47 (12) :2304-2307
[7]   Synthesis of 3-(2-N,N-diethylaminoethoxy) indoles as potential 5-HT6 receptor ligands [J].
Alex, Karolin ;
Schwarz, Nicolle ;
Khedkar, Vivek ;
Sayyed, Iliyas Ali ;
Tillack, Annegret ;
Michalik, Dirk ;
Holenz, Joerg ;
Diaz, Jose Luis ;
Beller, Matthias .
ORGANIC & BIOMOLECULAR CHEMISTRY, 2008, 6 (10) :1802-1807
[8]  
[Anonymous], ANGELS CHEM
[9]  
[Anonymous], ANGEW CHEM
[10]  
[Anonymous], 2004, ANGEW CHEM, V116, P3448
12345678910