Revisiting Campylobacter jejuni Virulence and Fitness Factors: Role in Sensing, Adapting, and Competing

被引：51

作者：

Elmi, Abdi ^{[1
]}

Nasher, Fauzy ^{[1
]}

Dorrell, Nick ^{[1
]}

Wren, Brendan ^{[1
]}

Gundogdu, Ozan ^{[1
]}

机构：

[1] London Sch Hyg & Trop Med, Fac Infect & Trop Dis, London, England

来源：

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2021年 / 10卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

Campylobacter jejuni; virulence; host-pathogen; sensing; adaptation; stress and survival; GUILLAIN-BARRE-SYNDROME; HUMAN EPITHELIAL-CELLS; BIOFILM FORMATION; CAPSULAR POLYSACCHARIDE; OXIDATIVE STRESS; HOST-CELL; ENVIRONMENTAL SURVIVAL; PROTEIN GLYCOSYLATION; FUNCTIONAL-ANALYSIS; SIGNALING PATHWAYS;

D O I：

10.3389/fcimb.2020.607704

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Campylobacter jejuni is the leading cause of bacterial foodborne gastroenteritis world wide and represents a major public health concern. Over the past two decades, significant progress in functional genomics, proteomics, enzymatic-based virulence profiling (EBVP), and the cellular biology of C. jejuni have improved our basic understanding of this important pathogen. We review key advances in our understanding of the multitude of emerging virulence factors that influence the outcome of C. jejuni-mediated infections. We highlight, the spatial and temporal dynamics of factors that promote C. jejuni to sense, adapt and survive in multiple hosts. Finally, we propose cohesive research directions to obtain a comprehensive understanding of C. jejuni virulence mechanisms.

引用

页数：15

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