Notch Signalling: Receptor cis-Inhibition To Achieve Directionality

被引：17
|
作者：
del Alamo, David [1 ]
Schweisguth, Francois [1 ]
机构：
[1] Inst Pasteur, CNRS, URA2578, F-75724 Paris 15, France
来源：
CURRENT BIOLOGY | 2009年 / 19卷 / 16期
关键词：
R7; PHOTORECEPTOR; DROSOPHILA; DELTA; ENDOCYTOSIS; SERRATE; PATHWAY;
D O I：
10.1016/j.cub.2009.07.025
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Lateral inhibition, by which single cells become distinct from their neighbours, can be mediated by Notch signalling during animal development. Signalling directionality is presumably achieved by downregulation of the Notch ligand in signal-receiving cells. New evidence suggests that cis-inhibition of the receptor in the ligand-sending cell might also provide directionality.
引用
收藏
页码：R683 / R684
页数：2
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