Notch Signalling: Receptor cis-Inhibition To Achieve Directionality

被引：17

作者：

del Alamo, David ^{[1
]}

Schweisguth, Francois ^{[1
]}

机构：

[1] Inst Pasteur, CNRS, URA2578, F-75724 Paris 15, France

来源：

CURRENT BIOLOGY | 2009年 / 19卷 / 16期

关键词：

R7; PHOTORECEPTOR; DROSOPHILA; DELTA; ENDOCYTOSIS; SERRATE; PATHWAY;

D O I：

10.1016/j.cub.2009.07.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lateral inhibition, by which single cells become distinct from their neighbours, can be mediated by Notch signalling during animal development. Signalling directionality is presumably achieved by downregulation of the Notch ligand in signal-receiving cells. New evidence suggests that cis-inhibition of the receptor in the ligand-sending cell might also provide directionality.

引用

页码：R683 / R684

页数：2

共 13 条

[1] Notch signalling: a simple pathway becomes complex [J].

Bray, Sarah J. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2006, 7 (09) :678-689

[2] R7 photoreceptor specification requires Notch activity [J].

Cooper, MTD ;

Bray, SJ .

CURRENT BIOLOGY, 2000, 10 (23) :1507-1510

[3] A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition [J].

Cordle, Jemima ;

Johnson, Steven ;

Tay, Joyce Zi Yan ;

Roversi, Pietro ;

Wilkin, Marian B. ;

de Madrid, Beatriz Hernandez ;

Shimizu, Hideyuki ;

Jensen, Sacha ;

Whiteman, Pat ;

Jin, Boquan ;

Redfield, Christina ;

Baron, Martin ;

Lea, Susan M. ;

Handford, Penny A. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2008, 15 (08) :849-857

[4] Signal integration during development: Mechanisms of EGFR and notch pathway function and cross-talk [J].

Doroquez, David B. ;

Rebay, Ilaria .

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2006, 41 (06) :339-385

[5] Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis [J].

Glittenberg, Marcus ;

Pitsouli, Chrysoula ;

Garvey, Clare ;

Delidakis, Christos ;

Bray, Sarah .

EMBO JOURNAL, 2006, 25 (20) :4697-4706

[6] THE CHOICE OF CELL FATE IN THE EPIDERMIS OF DROSOPHILA [J].

HEITZLER, P ;

SIMPSON, P .

CELL, 1991, 64 (06) :1083-1092

[7] Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of Delta [J].

Lai, EC ;

Deblandre, GA ;

Kintner, C ;

Rubin, GM .

DEVELOPMENTAL CELL, 2001, 1 (06) :783-794

[8]

Micchelli CA, 1997, DEVELOPMENT, V124, P1485

[9] cis-Inhibition of Notch by Endogenous Delta Biases the Outcome of Lateral Inhibition [J].

Miller, Adam C. ;

Lyons, Eric L. ;

Herman, Tory G. .

CURRENT BIOLOGY, 2009, 19 (16) :1378-1383

[10] neuralized encodes a peripheral membrane protein involved in Delta signaling and endocytosis [J].

Pavlopoulos, E ;

Pitsouli, C ;

Klueg, KM ;

Muskavitch, AT ;

Moschonas, NK ;

Delidakis, C .

DEVELOPMENTAL CELL, 2001, 1 (06) :807-816

← 1 2 →