Synergistic effects between aminoethyl-chitosans and β-lactams against methicillin-resistant Staphylococcus aureus (MRSA)

被引：9
|
作者：
Lee, Dae-Sung [5 ]
Kim, Young-Mog [4 ]
Lee, Myung-Suk [5 ]
Ahn, Chang-Bum [2 ]
Jung, Won-Kyo [1 ,3 ]
Je, Jae-Young [2 ]
机构：
[1] Chosun Univ, Dept Marine Life Sci, Kwangju 501759, South Korea
[2] Chonnam Natl Univ, Sch Food Technol & Nutr, Yeosu 550749, South Korea
[3] Chosun Univ, Marine Life Res Ctr, Kwangju 501759, South Korea
[4] Pukyong Natl Univ, Dept Food Sci & Technol, Pusan 608737, South Korea
[5] Pukyong Natl Univ, Dept Microbiol, Pusan 608737, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 03期
关键词：
MRSA; Antimicrobial agent; Aminoderivatized chitosans; Synegistic effect; DERIVATIVES;
D O I：
10.1016/j.bmcl.2009.12.049
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two kinds of aminoethyl-chitosans (AEC), AEC90 and AEC50, which had degrees of deacetylation of 90% and 50%, respectively, were prepared and their synergistic effects in combination with beta-lactams including ampicillin, penicillin, and oxacillin against two standard methicillin-resistant Staphylococcus aureus (MRSA) strains and twelve clinical isolated MRSA strains were investigated. When AECs and beta-lactams were combined, synergistic effects were observed with fractional inhibitory concentration (FIC) indices of 0.252-0.508, and the MICs of beta-lactams in the presence of AECs were dramatically reduced. (c) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：975 / 978
页数：4
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