IL-1 family and Cutaneous Leishmaniasis: A poorly understood relationship

被引：8

作者：

da Silva Amorim, Ester Alves ^{[1
,2
]}

de Franca, Aquila Alcantara ^{[1
,2
]}

Alves Pereira, Valeria Rego ^{[2
]}

Accioly Brelaz-de-Castro, Maria Carolina ^{[1
,2
]}

机构：

[1] Fed Univ Pernambuco UFPE, Acad Ctr Vitoria CAV, Rua Alto Reservatorio S-N, BR-55608680 Vitoria De Santo Antao, PE, Brazil

[2] Oswaldo Cruz Pernambuco Fdn Fiocruz PE, Dept Immunol, Av Moraes Rego S-N,Cidade Univ, BR-50670420 Recife, PE, Brazil

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2021年 / 57卷

关键词：

IL-1; family; Cytokines; Cutaneous leishmaniasis; Inflammation; Immune response;

D O I：

10.1016/j.cytogfr.2020.06.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cytokines of the interleukin (IL)-1 family act in the initiation of an effective immune response in Leishmania infection, represented mainly by the T helper 1 (Th1) profile, in addition to being associated with disease exacerbation and controversial contributions in the Th2 responses. The family also includes members who self regulate inflammation, such as antagonists and anti-inflammatory cytokines, most of which have not yet been studied in Cutaneous Leishmaniasis (CL) in humans. Here we summarize findings about what is known so far about the role of these cytokines in mice, the main study model, and in humans. We reinforce the importance of studies of these cytokines as new targets in the context of CL.

引用

页码：85 / 92

页数：8

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