Inorganic Nanoparticle-Loaded Exosomes for Biomedical Applications

被引：33

作者：

Barjesteh, Taraneh ^{[1
]}

Mansur, Shomit ^{[1
]}

Bao, Yuping ^{[1
]}

机构：

[1] Univ Alabama, Dept Chem & Biol Engn, Box 870203, Tuscaloosa, AL 35487 USA

来源：

MOLECULES | 2021年 / 26卷 / 04期

基金：

美国国家科学基金会;

关键词：

exosomes; inorganic nanoparticles; bioimaging; biomimetic nanocarriers; theranostics;

D O I：

10.3390/molecules26041135

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Exosomes are intrinsic cell-derived membrane vesicles in the size range of 40-100 nm, serving as great biomimetic nanocarriers for biomedical applications. These nanocarriers are known to bypass biological barriers, such as the blood-brain barrier, with great potential in treating brain diseases. Exosomes are also shown to be closely associated with cancer metastasis, making them great candidates for tumor targeting. However, the clinical translation of exosomes are facing certain critical challenges, such as reproducible production and in vivo tracking of their localization, distribution, and ultimate fate. Recently, inorganic nanoparticle-loaded exosomes have been shown great benefits in addressing these issues. In this review article, we will discuss the preparation methods of inorganic nanoparticle-loaded exosomes, and their applications in bioimaging and therapy. In addition, we will briefly discuss their potentials in exosome purification.

引用

页数：14

共 52 条

[1] Human mesenchymal stem cell-derived iron oxide exosomes allow targeted ablation of tumor cells via magnetic hyperthermia [J].

Altanerova, U. ;

Babincova, M. ;

Babinec, P. ;

Benejova, K. ;

Jakubechova, J. ;

Altanerova, V. ;

Zduriencikova, M. ;

Repiska, V. ;

Altaner, C. .

INTERNATIONAL JOURNAL OF NANOMEDICINE, 2017, 12 :7923-7936

[2] Size and Surface Functionalization of Iron Oxide Nanoparticles Influence the Composition and Dynamic Nature of Their Protein Corona [J].

Ashby, Jonathan ;

Pan, Songqin ;

Zhong, Wenwan .

ACS APPLIED MATERIALS & INTERFACES, 2014, 6 (17) :15412-15419

[3] Magnetic nanoparticles: material engineering and emerging applications in lithography and biomedicine [J].

Bao, Yuping ;

Wen, Tianlong ;

Samia, Anna Cristina S. ;

Khandhar, Amit ;

Krishnan, Kannan M. .

JOURNAL OF MATERIALS SCIENCE, 2016, 51 (01) :513-553

[4] Advances in imaging strategies for in vivo tracking of exosomes [J].

Betzer, Oshra ;

Barnoy, Eran ;

Sadan, Tamar ;

Elbaz, Idan ;

Braverman, Cara ;

Liu, Zhuang ;

Popovtzer, Rachela .

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 2020, 12 (02)

[5] In Vivo Neuroimaging of Exosomes Using Gold Nanoparticles [J].

Betzer, Oshra ;

Perets, Nisim ;

Ange, Ariel ;

Motiei, Menachem ;

Sadan, Tamar ;

Yadid, Gal ;

Offen, Daniel ;

Popovtzer, Rachela .

ACS NANO, 2017, 11 (11) :10883-10893

[6] Tumor Cell-Derived Extracellular Vesicle-Coated Nanocarriers: An Efficient Theranostic Platform for the Cancer-Specific Delivery of Anti-miR-21 and Imaging Agents [J].

Bose, Rajendran J. C. ;

Kumar, Sukumar Uday ;

Zeng, Yitian ;

Afjei, Rayhaneh ;

Robinson, Elise ;

Lau, Kenneth ;

Bermudez, Abel ;

Habte, Frezghi ;

Pitteri, Sharon J. ;

Sinclair, Robert ;

Willmann, Juergen K. ;

Massoud, Tarik F. ;

Gambhir, Sanjiv S. ;

Paulmurugan, Ramasamy .

ACS NANO, 2018, 12 (11) :10817-10832

[7] Stem cell tracking using iron oxide nanoparticles [J].

Bull, Elizabeth ;

Madani, Seyed Yazdan ;

Sheth, Roosey ;

Seifalian, Amelia ;

Green, Mark ;

Seifalian, Alexander M. .

INTERNATIONAL JOURNAL OF NANOMEDICINE, 2014, 9 :1641-1653

[8] Magnetic resonance imaging of ultrasmall superparamagnetic iron oxide-labeled exosomes from stem cells: a new method to obtain labeled exosomes [J].

Busato, Alice ;

Bonafede, Roberta ;

Bontempi, Pietro ;

Scambi, Ilaria ;

Schiaffino, Lorenzo ;

Benati, Donatella ;

Malatesta, Manuela ;

Sbarbati, Andrea ;

Marzola, Pasquina ;

Mariotti, Raffaella .

INTERNATIONAL JOURNAL OF NANOMEDICINE, 2016, 11 :2481-2490

[9] Engineered Exosome-Mediated Near-Infrared-II Region V2C Quantum Dot Delivery for Nucleus-Target Low-Temperature Photothermal Therapy [J].

Cao, Yu ;

Wu, Tingting ;

Zhang, Kai ;

Meng, Xiangdan ;

Dai, Wenhao ;

Wang, Dongdong ;

Dong, Haifeng ;

Zhang, Xueji .

ACS NANO, 2019, 13 (02) :1499-1510

[10] Exosome purification based on PEG-coated Fe3O4 nanoparticles [J].

Chang, Ming ;

Chang, Yaw-Jen ;

Chao, Pei Yu ;

Yu, Qing .

PLOS ONE, 2018, 13 (06)

← 1 2 3 4 5 6 →