Male infertility

被引：748

作者：

Agarwal, Ashok ^{[1
]}

Baskaran, Saradha ^{[1
]}

Parekh, Neel ^{[2
]}

Cho, Chak-Lam ^{[3
]}

Henkel, Ralf ^{[1
,4
,5
]}

Vij, Sarah ^{[2
]}

Arafa, Mohamed ^{[6
,7
]}

Selvam, Manesh Kumar Panner ^{[1
]}

Shah, Rupin ^{[8
]}

机构：

[1] Cleveland Clin, Amer Ctr Reprod Med, Cleveland, OH 44195 USA

[2] Cleveland Clin, Dept Urol, Cleveland, OH 44106 USA

[3] Chinese Univ Hong Kong, Dept Surg, SH Ho Urol Ctr, Hong Kong, Peoples R China

[4] Univ Western Cape, Dept Med Biosci, Bellville, South Africa

[5] Imperial Coll London, Dept Metab Digest & Reprod, London, England

[6] Hamad Med Corp, Dept Urol, Male Infertil Unit, Doha, Qatar

[7] Cairo Univ, Androl Dept, Cairo, Egypt

[8] Lilavati Hosp & Res Ctr, Dept Urol, Mumbai, Maharashtra, India

来源：

LANCET | 2021年 / 397卷 / 10271期

关键词：

INTRACYTOPLASMIC SPERM INJECTION; CLINICAL-PRACTICE GUIDELINES; SEMEN QUALITY; NONOBSTRUCTIVE AZOOSPERMIA; VAGINAL LUBRICANTS; DNA FRAGMENTATION; OXIDATIVE STRESS; MALE-FERTILITY; REPRODUCTIVE OUTCOMES; PSYCHOLOGICAL STRESS;

D O I：

10.1016/S0140-6736(20)32667-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It is estimated that infertility affects 8-12% of couples globally, with a male factor being a primary or contributing cause in approximately 50% of couples. Causes of male subfertility vary highly, but can be related to congenital, acquired, or idiopathic factors that impair spermatogenesis. Many health conditions can affect male fertility, which underscores the need for a thorough evaluation of patients to identify treatable or reversible lifestyle factors or medical conditions. Although semen analysis remains the cornerstone for evaluating male infertility, advanced diagnostic tests to investigate sperm quality and function have been developed to improve diagnosis and management. The use of assisted reproductive techniques has also substantially improved the ability of couples with infertility to have biological children. This Seminar aims to provide a comprehensive overview of the assessment and management of men with infertility, along with current controversies and future endeavours.

引用

页码：319 / 333

页数：15

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