Generation of Bioactive Materials with Rapid Self-Assembling Resorcinarene-Peptides

被引：6

作者：

Charnley, Mirren ^{[1
]}

Fairfull-Smith, Kathryn ^{[2
]}

Haldar, Saubhik ^{[2
]}

Elliott, Richard ^{[1
]}

McArthur, Sally L. ^{[1
]}

Williams, Nicholas H. ^{[2
]}

Haycock, John W. ^{[1
]}

机构：

[1] Univ Sheffield, Dept Mat Engn, Kroto Res Inst, Sheffield S3 7HQ, S Yorkshire, England

[2] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England

来源：

ADVANCED MATERIALS | 2009年 / 21卷 / 28期

基金：

英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;

关键词：

MELANOCYTE-STIMULATING HORMONE; KAPPA-B ACTIVATION; ALPHA-MSH PEPTIDES; INFLAMMATORY RESPONSES; ANTIINFLAMMATORY ACTIVITY; SURFACE-CHEMISTRY; OXIDE SURFACES; IN-VITRO; CELLS; EXPRESSION;

D O I：

10.1002/adma.200802731

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Adhesive resorcinarene molecules rapidly self-assemble on a wide range of material surfaces. We have created resorcinarenes that contain a biologically active terminal GKP-D-V anti-inflammatory peptide by a rapid "dip-and-dry" forming method. The growth of neural Schwann and fibroblast cells on a layer of resorcinarene-GKP-D-V demonstrate inhibition of inflammatory signaling.

引用

页码：2909 / 2915

页数：7

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