Gold(I)-catalyzed 5-endo hydroxy- and alkoxycyclization of 1,5-enynes:: Efficient access to functionalized cyclopentenes

被引：128

作者：

Buzas, Andrea K. ^{[1
]}

Istrate, Florin M. ^{[1
]}

Gagosz, Fabien ^{[1
]}

机构：

[1] Ecole Polytech, Organ Synth Lab, CNRS, UMR 7652, F-91128 Palaiseau, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 07期

关键词：

C-C coupling; cyclization; cyclopentenes; gold; metathesis;

D O I：

10.1002/anie.200604140

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) The rapid and stereoselective construction of highly functionalized cyclopentenes is possible through gold(I)-catalyzed 5-endo hydroxy- and methoxycyclizations of 1,5-enynes. More complex 5,7-and 5,8-fused bicyclic structures of a type found in many terpene natural products can be formed by combining the cyclization reaction with ring-closing metathesis (RCM; see scheme). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1141 / 1144

页数：4

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