Microwave promoted Pd-catalyzed cyanation of aryl triflates: A fast and versatile access to 3-cyano-3-desoxy-10-ketomorphinans

被引：70

作者：

Zhang, A ^{[1
]}

Neumeyer, JL ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, McLean Hosp,Med Chem Program, Alcohol & Drug Abuse Res Ctr, Belmont, MA 02478 USA

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 02期

关键词：

D O I：

10.1021/ol027256p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A methodology for the microwave-promoted conversion of triflates to the corresponding nitriles by using 8% equiv of Pd(Ph3P)(4) as the catalyst and 2.0 equiv of Zn(CN)(2) as the cyanide source has been developed. This method is highly efficient for the preparation of 3-cyano-3-desoxy10-ketomorphinans. The reaction was generally completed in 15 min at 200 degreesC and produced products in greater than 86% yields.

引用

页码：201 / 203

页数：3

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