Translational Relevance of Mouse Models of Atopic Dermatitis

被引：14

作者：

Choi, Justin ^{[1
,2
]}

Sutaria, Nishadh ^{[1
]}

Roh, Youkyung Sophie ^{[1
]}

Bordeaux, Zachary ^{[1
]}

Alphonse, Martin P. ^{[1
]}

Kwatra, Shawn G. ^{[1
]}

Kwatra, Madan M. ^{[2
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Dermatol, Baltimore, MD 21231 USA

[2] Duke Univ, Sch Med, Dept Anesthesiol, Durham, NC 27710 USA

来源：

JOURNAL OF CLINICAL MEDICINE | 2021年 / 10卷 / 04期

关键词：

atopic dermatitis; eczema; mouse models; dermatology; immunology;

D O I：

10.3390/jcm10040613

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The complexity of atopic dermatitis (AD) continues to present a challenge in the appropriate selection of a mouse model because no single murine model completely recapitulates all aspects of human AD. This has been further complicated by recent evidence of the distinct AD endotypes that are dictated by unique patterns of inflammation involving Th1, Th2, Th17, and Th22 axes. A review of currently used mouse models demonstrates that while all AD mouse models consistently exhibit Th2 inflammation, only some demonstrate concomitant Th17 and/or Th22 induction. As the current understanding of the pathogenic contributions of these unique endotypes and their potential therapeutic roles expands, ongoing efforts to maximize a given mouse model's homology with human AD necessitates a close evaluation of its distinct immunological signature.

引用

页码：1 / 11

页数：11

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