A sesquiterpene glycoside and phenylalanine derivatives from Tinospora sinensis

被引：10

作者：

Huang, Liping ^{[1
]}

Luo, Dezhi ^{[1
]}

Fu, Rongrong ^{[2
]}

Yan, Bo ^{[1
]}

Wang, Xiaobing ^{[3
]}

Shu, Jicheng ^{[2
]}

Deng, Jiao ^{[1
]}

Huang, Huilian ^{[2
]}

机构：

[1] Jiangxi Univ Tradit Chinese Med, Coll Pharm, Nanchang 330004, Jiangxi, Peoples R China

[2] Jiangxi Univ Tradit Chinese Med, Key Lab Modern Preparat TCM, Minist Educ, Nanchang 330004, Jiangxi, Peoples R China

[3] China Pharmaceut Univ, State Key Lab Nat Med, Dept Nat Med Chem, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China

来源：

FITOTERAPIA | 2019年 / 137卷

基金：

中国国家自然科学基金;

关键词：

Tinospora sinensis; Sesquiterpene glycoside; Amide;

D O I：

10.1016/j.fitote.2019.104247

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new sesquiterpene glycoside and a new amide have been isolated from the stems of Tinospora sinensis. Their structures were established by 2D NMR spectroscopic techniques (H-1,H-1-COSY, NOESY, HSQC and HMBC) and mass spectrometry. The isolated compounds were subjected to evaluate neuroprotective activities in vitro. The pre-treatment of two new compounds can significantly ameliorate damage of oxidative stress induced by A beta(25-35) and improve PC12 cells survival.

引用

页数：7

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