Clinical profiles of celecoxib and rofecoxib in the rheumatic diseases

被引：0
作者：
Gibofsky, A [1 ]
机构：
[1] Cornell Univ, Weill Med Coll, New York, NY 10021 USA
来源：
JOURNAL OF HYPERTENSION | 2002年 / 20卷
关键词：
osteoarthritis; rheumatoid arthritis; cyclooxygenase; non-steroidal anti-inflammatory drugs;
D O I：
暂无
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Celecoxib and rofecoxib are highly specific cyclooxygenase-2 inhibitors. Both agents are as effective as conventional, non-selective non-steroidal anti-inflammatory drugs (NSAIDs) but they have a markedly reduced propensity to cause injury to the gastroduodenal mucosa compared with conventional NSAIDs. Celecoxib and rofecoxib are approved for treatment of both osteoarthritis and rheumatoid arthritis. This presentation reviews the mechanism of action of these agents, the clinical studies showing their effectiveness for treatment of arthritis, and the gastrointestinal side effect profiles compared with conventional NSAIDs. (C) 2002 Lippincott Williams Wilkins.
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页码：S25 / S30
页数：6
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