Simplified intraoperative parathormone assay for primary hyperparathyroidism in a resource-limited setting

被引：0

作者：

Rajan, Sendhil ^{[1
]}

Ravindhran, Bharadhwaj ^{[1
]}

George, Belinda ^{[2
]}

Bantwal, Ganapathy ^{[2
]}

Ayyar, Vaagesh ^{[2
]}

Manjuanth, Suraj ^{[3
]}

机构：

[1] St Johns Med Coll, Dept Gen Surg, Bengaluru, India

[2] St Johns Med Coll, Dept Endocrinol, Bengaluru, India

[3] St Johns Med Coll, Dept Surg Oncol, Bengaluru, India

来源：

BIOMARKERS IN MEDICINE | 2021年 / 15卷 / 05期

关键词：

intraoperative care; parathormone decline; parathyroidectomy; prediction;

D O I：

10.2217/bmm-2020-0225

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background: The optimum threshold of IOPTH decay remains a debate and numerous criteria have been described. In this study, we utilize a single-sample IOPTH taken 10 min post excision. Materials & methods: This 4-year query of a prospectively maintained database included primary hyperparathyroidism patients with pre-operative PTH done 1 week prior to surgery, and a 10-min post excision IOPTH value. Optimal cut-off for PTH and sensitivity/specificity were calculated. Results: A total of 93 patients had single-gland disease, of whom 79 (84.9%) were symptomatic. The 10-min post excision assay sensitivity in single-gland disease was 97.8% (50% fall), 95% (60% fall) and 83.9% (70% fall). Conclusion: A post excision single-shot IOPTH assay with a 50% fall offers a sensitivity of 97.8% in patients of primary hyperparathyroidism with single-gland benign disease.

引用

页码：331 / 336

页数：6