Acute myelofibrosis: multifocal bone marrow infiltration detected by scintigraphy and magnetic resonance imaging

被引:3
作者
Olipitz, W
Beham-Schmid, C
Aigner, R
Raith, J
Linkesch, W
Sill, H
机构
[1] Karl Franzens Univ Graz, Sch Med, Dept Med, Div Hematol, A-8036 Graz, Austria
[2] Karl Franzens Univ Graz, Sch Med, Dept Pathol, A-8036 Graz, Austria
[3] Karl Franzens Univ Graz, Sch Med, Dept Radiol, Div Nucl Med, A-8036 Graz, Austria
[4] Karl Franzens Univ Graz, Sch Med, Dept Magnet Resonance Imaging, A-8036 Graz, Austria
关键词
acute myelofibrosis; acute megakaryoblastic leukemia; scintigraphy; magnetic resonance imaging; interferon gamma;
D O I
10.1007/s002770050593
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Acute myelofibrosis is a rare, malignant hematological disorder of unknown etiology with an inevitably fatal outcome. Here we present the study of a 63-year-old Caucasian man with acute onset of pancytopenia. Repeated bone marrow biopsies showed dense fibrosis and hypoplastic hematopoiesis raising various differential diagnoses of malignant and nonmalignant conditions. Bone marrow scintigraphy and magnetic resonance imaging (MRI) showed areas suggesting neoplastic infiltration, mainly in both femurs and tibias. Histological examination of a surgical biopsy of the left tibia revealed acute megakaryoblastic leukemia. As the patient refused polychemotherapy, therapy with interferon gamma was initiated but discontinued prematurely because of intolerable side effects. The presented case therefore suggests that the combination of bone marrow scintigraphy and MRI is a valuable diagnostic tool in patients presenting with myelofibrosis of unknown origin.
引用
收藏
页码:275 / 278
页数:4
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