Low Expression LncRNA TUBA4B is a Poor Predictor of Prognosis and Regulates Cell Proliferation in Non-Small Cell Lung Cancer

被引：35
作者：
Chen, Jian [1 ]
Hu, Lijuan [1 ]
Wang, Junjun [1 ]
Zhang, Fan [1 ]
Chen, Jie [2 ]
Xu, Gang [1 ]
Wang, Yumin [1 ]
Pan, Qinshi [1 ]
机构：
[1] Wenzhou Med Univ, Dept Lab Med, Affiliated Hosp 1, Wenzhou 325000, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Dept Intens Care Unit, Affiliated Hosp 1, Wenzhou 325000, Zhejiang, Peoples R China
来源：
PATHOLOGY & ONCOLOGY RESEARCH | 2017年 / 23卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Non-small cell lung cancer; lncRNAs; TUBA4B; Prognosis; LONG NONCODING RNA; PROSTATE-CANCER; GENE; METASTASIS; SURVIVAL; NSCLC; STATE;
D O I：
10.1007/s12253-016-0089-y
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We aimed to unveil the clinical roles and biological function of lncRNA TUBA4B in on-small cell lung cancer (NSCLC). The relative expression level of TUBA4B was estimated by qPCR in 114 pairs of NSCLC and NT samples and the relation of TUBA4B to clinical data of NSCLC patients was analyzed. We found TUBA4B was lower expressed in NSCLC and five cell lines. The lower expression of TUBA4B was remarkably correlated with advanced TNM stage and lymph node metastasis and served as a predictor for overall survival of NSCLC. After overexpression of TUBA4B, cell proliferation ability of A549 and NCI-H1299 remarkably decreased. Our study ascertained low expression TUBA4B in NSCLC tissue, cell lines and is a poor predictor for prognosis and can regulate cell proliferation in NSCLC.
引用
收藏
页码：265 / 270
页数：6
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