Linezolid Consumption Facilitates the Development of Linezolid Resistance in Enterococcus faecalis in a Tertiary-Care Hospital: A 5-Year Surveillance Study

被引:17
作者
Bai, Bing [1 ,2 ,3 ]
Hu, Kaitao [1 ,2 ,3 ]
Zeng, Jun [4 ]
Yao, Weiming [1 ,2 ,3 ]
Li, Duoyun [1 ,2 ,3 ]
Pu, Zhangya [1 ,2 ,3 ]
Chen, Zhong [1 ,2 ,3 ]
Cheng, Hang [1 ,2 ,3 ]
Zheng, Jinxin [1 ,2 ,3 ,5 ,6 ,7 ]
Pan, Weiguang [1 ,2 ,3 ]
Lin, Zhiwei [1 ,2 ,3 ,5 ,6 ,7 ]
Xie, Lixia [1 ,2 ,3 ,8 ]
Deng, Qiwen [1 ,2 ,3 ]
Yu, Zhijian [1 ,2 ,3 ,8 ]
机构
[1] Shenzhen Univ, Shenzhen Nanshan Hosp, Dept Infect Dis, 89 Taoyuan Rd, Shenzhen 518052, Peoples R China
[2] Shenzhen Univ, Shenzhen Nanshan Hosp, Shenzhen Key Lab Endogenous Infect, 89 Taoyuan Rd, Shenzhen 518052, Peoples R China
[3] Qual Control Ctr Hosp Infect Management Shenzhen, Shenzhen, Peoples R China
[4] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Dept Digest Dis, Tongji Med Coll, Wuhan, Hubei, Peoples R China
[5] Fudan Univ, Key Lab Med Mol Virol, Minist Educ, Sch Basic Med Sci,Shanghai Med Coll, Shanghai, Peoples R China
[6] Fudan Univ, Key Lab Med Mol Virol, Minist Hlth, Sch Basic Med Sci,Shanghai Med Coll, Shanghai, Peoples R China
[7] Fudan Univ, Inst Biomed Sci, Shanghai Med Coll, Shanghai, Peoples R China
[8] Univ Houston, Dept Pharm Practice & Translat Res, Houston, TX USA
基金
中国国家自然科学基金;
关键词
Enterococcus faecalis; linezolid resistance; FAECIUM; INFECTION; OUTBREAK; REVEALS;
D O I
10.1089/mdr.2018.0005
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Although case reports and clinical studies of linezolid (LZD)-resistant Enterococcus faecalis (LREF) have gradually increased in recent years, the relationship between LZD resistance and antibiotic consumption in hospital settings still remains unclear. In this study, we aimed to investigate the dynamic relationship between the yearly detection frequency of LREF clinical isolates and yearly consumption of LZD and vancomycin (VCM) over a 5-year period in a Chinese hospital setting. Antibiotic consumption data (LZD and VCM) from 2011 to 2015 were obtained from a computerized database and recalculated as the defined daily doses (DDDs) per 100 bed-days (DBD). All 268 E. faecalis clinical isolates were retrospectively collected from 2011 to 2015 in this hospital. LZD resistance mechanism and multilocus sequence typing of E. faecalis were determined by PCR. The annual detection frequency of LREF clinical isolates tested in this hospital was shown with 1.89% (1/53), 2% (1/50), 2.04% (1/49), 0% (0/45), and 7.04% (5/71), respectively, and the detection frequency of LZD-nonsusceptible E. faecalis (LNSEF; n = 59, including LZD-resistant and intermediate isolates) was determined with 26.42% (14/53), 34% (17/50), 16.33% (8/49), 22.22% (10/45), and 14.08% (10/71), respectively. Spearman correlation analysis revealed that LZD DBD significantly correlated positively with the detection frequency of LREF (r = 0.886, p = 0.019). Moreover, VCM DBD significantly correlated positively with the frequency of LNSEF (r = 0.943, p = 0.005). Furthermore, the detection frequency of optrA-positive E. faecalis also correlated positively with high LZD consumption load in this hospital setting. Conclusively, high LZD consumption load facilitates the development of LZD resistance and promotes the selection of optrA-positive E. faecalis clinical isolates under antibiotic pressure in a hospital setting.
引用
收藏
页码:791 / 798
页数:8
相关论文
共 28 条
  • [1] Ipsilateral lung dose volume parameters predict radiation pneumonitis in addition to classical dose volume parameters in locally advanced NSCLC treated with combined modality therapy
    Agrawal, Sushma
    Kumar, Sunil
    Lawrence, Able
    Das, Maria K. J.
    Kumar, Shaleen
    [J]. SOUTH ASIAN JOURNAL OF CANCER, 2014, 3 (01) : 13 - 15
  • [2] Amberpet R., 2016, J CLIN DIAGN RES, V9, pDC06
  • [3] Systematic Review and Meta-Analysis of Linezolid versus Daptomycin for Treatment of Vancomycin-Resistant Enterococcal Bacteremia
    Balli, Eleni P.
    Venetis, Chris A.
    Miyakis, Spiros
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (02) : 734 - 739
  • [4] The emerging problem of linezolid-resistant enterococci
    Bi, Ruru
    Qin, Tingting
    Fan, Wenting
    Ma, Ping
    Gu, Bing
    [J]. JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, 2018, 13 : 11 - 19
  • [5] Dose dependence of emergence of resistance to linezolid in Enterococcus faecalis in vivo
    Bourgeois-Nicolaos, Nadege
    Massias, Laurent
    Couson, Brigitte
    Butel, Marie-Jose
    Andremont, Antoine
    Doucet-Populaire, Florence
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2007, 195 (10) : 1480 - 1488
  • [6] Cai J., 2015, ENTEROCOCCAL ISOLATE, V12
  • [7] Detection of a New cfr-Like Gene, cfr(B), in Enterococcus faecium Isolates Recovered from Human Specimens in the United States as Part of the SENTRY Antimicrobial Surveillance Program
    Deshpande, Lalitagauri M.
    Ashcraft, Deborah S.
    Kahn, Heather P.
    Pankey, George
    Jones, Ronald N.
    Farrell, David J.
    Mendes, Rodrigo E.
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2015, 59 (10) : 6256 - 6261
  • [8] Diaz L., 2012, AGENTS CHEMOTHER, V7, P3917
  • [9] Proteomic and Transcriptomic Analysis of Linezolid Resistance in Streptococcus pneumoniae
    Feng, Jie
    Billal, Dewan S.
    Lupien, Andreanne
    Racine, Gina
    Winstall, Eric
    Legare, Danielle
    Leprohon, Philippe
    Ouellette, Marc
    [J]. JOURNAL OF PROTEOME RESEARCH, 2011, 10 (10) : 4439 - 4452
  • [10] Genome sequencing of linezolid-resistant Streptococcus pneumoniae mutants reveals novel mechanisms of resistance
    Feng, Jie
    Lupien, Andreanne
    Gingras, Helene
    Wasserscheid, Jessica
    Dewar, Ken
    Legare, Danielle
    Ouellette, Marc
    [J]. GENOME RESEARCH, 2009, 19 (07) : 1214 - 1223