Diagnosis of disseminated intravascular coagulation by hemostatic molecular markers

被引:26
|
作者
Wada, H
Gabazza, E
Nakasaki, T
Shimura, M
Hiyoyama, K
Deguchi, K
Nishikawa, M
Sakuragawa, N
Shiku, H
机构
[1] Mie Univ, Sch Med, Dept Internal Med 2, Tsu, Mie, Japan
[2] Mie Univ, Sch Med, Dept Internal Med 3, Tsu, Mie, Japan
[3] Toyama Med & Pharmaceut Univ, Dept Clin Pharmacol, Toyama, Japan
来源
SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2000年 / 26卷 / 01期
关键词
DIC; pre-DIC; TAT; PPIC; sFM;
D O I
10.1055/s-2000-9797
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In the present study, the positive rate of thrombin-antithrombin complex (TAT), plasmin-plasmin inhibitor complex (PPIC), soluble fibrin monomer (sFM), and D-dimer for the diagnosis of disseminated intravascular coagulation (DIG) was evaluated. The study comprised 307 patients with DIG, 123 with pre-DIG, and 121 with non-DIG. Plasma levels of TAT, PPIC, sFM, and D-dimer were significantly higher in DIG and pre-DIG patients than in non-DIG patients. In DIG patients, the positive rate of sFM was high and that of D-dimer was low; the positive rate of PPIC was higher in patients with hematopoietic malignancy than in those without this disease. In pre-DIG patients, the positive rate of all markers was low (<0.16), and the positive rate of PPIC was relatively high. In non-DIG patients, the positive rate of all hemostatic markers was low (<0.16), that of sFM being the lowest. Scoring the positive rate of TAT, PPIC, and sFM disclosed the following results: 72% of DIG patients had three or more points, 17.6% of pre-DIG patients had three or more points, and almost all (96.6%) non-DIG patients had two or less points. Scoring the positive rate of TAT, PPIC, and D-dimer disclosed the following results: 52.9% of DIG patients and 27.4% of pre-DIG patients had three or more points and almost all (96.7%) non-DIG patients had 2 or less points. These data suggest that the combination of TAT, PPIC, and sFM is useful for making the diagnosis of DIC.
引用
收藏
页码:17 / 21
页数:5
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