A New and More Efficient Synthesis of Methylene Acetals

被引：8
|
作者：
Chu, Guobiao [1 ]
Zhang, Yanqiao [1 ]
Li, Chunbao [1 ]
Zhang, Yuqing [2 ]
机构：
[1] Tianjin Univ, Coll Sci, Dept Chem, Tianjin 300072, Peoples R China
[2] Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2009年 / 22期
关键词：
2,4-dichloro-6-methoxy[1,3,5]triazine; dimethyl sulfoxide; alcohols; benzyl chlorides; methylene acetals; DIMETHYL SULFOXIDE; ALCOHOLS; FORMALDEHYDE; DERIVATIVES;
D O I：
10.1055/s-0029-1216992
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new and efficient synthesis of benzyl chlorides and methylene acetals by use of 2,4-dichloro-6-methoxy[1,3,5]triazine (MeOTCT) and dimethyl sulfoxide has been developed. Chlorides are the major products for benzyl alcohols, while methylene acetals are the major products for secondary alcohols. This procedure provides the highest yields so far for methylene acetals of steroids. A plausible mechanism is proposed on the basis of the experiments.
引用
收藏
页码：3828 / 3832
页数：5
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