Induced gene expression in human brain after the split from chimpanzee

被引：91
作者：
Gu, JY [1 ]
Gu, X [1 ]
机构：
[1] Iowa State Univ, Dept Zool & Genet, Ames, IA 50011 USA
来源：
TRENDS IN GENETICS | 2003年 / 19卷 / 02期
关键词：
D O I：
10.1016/S0168-9525(02)00040-9
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Despite only similar to1% difference in genomic DNA sequence, humans and chimpanzees differ considerably in mental and linguistic capabilities, and in susceptibility to some diseases. A recent comparison of gene expression in human and great apes cast some light on the genetic basis of these differences, but more rigorous study is required. Our statistical reanalysis of these microarray data shows that there have indeed been dramatic alterations in the expression of genes in the human brain since the split from chimpanzees, mainly caused by a set of genes with increased (rather than decreased) expression in the human brain.
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收藏
页码：63 / 65
页数：3
相关论文
共 12 条
  • [1] A mixture model approach for the analysis of microarray gene expression data
    Allison, DB
    Gadbury, GL
    Heo, MS
    Fernández, JR
    Lee, CK
    Prolla, TA
    Weindruch, R
    [J]. COMPUTATIONAL STATISTICS & DATA ANALYSIS, 2002, 39 (01) : 1 - 20
  • [2] A Bayesian framework for the analysis of microarray expression data: regularized t-test and statistical inferences of gene changes
    Baldi, P
    Long, AD
    [J]. BIOINFORMATICS, 2001, 17 (06) : 509 - 519
  • [3] Dudoit S, 2002, STAT SINICA, V12, P111
  • [4] Intra- and interspecific variation in primate gene expression patterns
    Enard, W
    Khaitovich, P
    Klose, J
    Zöllner, S
    Heissig, F
    Giavalisco, P
    Nieselt-Struwe, K
    Muchmore, E
    Varki, A
    Ravid, R
    Doxiadis, GM
    Bontrop, RE
    Pääbo, S
    [J]. SCIENCE, 2002, 296 (5566) : 340 - 343
  • [5] Construction and analysis of a human-chimpanzee comparative clone map
    Fujiyama, A
    Watanabe, H
    Toyoda, A
    Taylor, TD
    Itoh, T
    Tsai, SF
    Park, HS
    Yaspo, ML
    Lehrach, H
    Chen, Z
    Fu, G
    Saitou, N
    Osoegawa, K
    de Jong, PJ
    Suto, Y
    Hattori, M
    Sakaki, Y
    [J]. SCIENCE, 2002, 295 (5552) : 131 - 134
  • [6] Toward a phylogenetic classification of primates based on DNA evidence complemented by fossil evidence
    Goodman, M
    Porter, CA
    Czelusniak, J
    Page, SL
    Schneider, H
    Shoshani, J
    Gunnell, G
    Groves, CP
    [J]. MOLECULAR PHYLOGENETICS AND EVOLUTION, 1998, 9 (03) : 585 - 598
  • [7] IRIZARRY RA, 2002, BIOSTATISTICS
  • [8] EVOLUTION AT 2 LEVELS IN HUMANS AND CHIMPANZEES
    KING, MC
    WILSON, AC
    [J]. SCIENCE, 1975, 188 (4184) : 107 - 116
  • [9] Improved statistical inference from DNA microarray data using analysis of variance and a Bayesian statistical framework -: Analysis of global gene expression in Escherichia coli K12
    Long, AD
    Mangalam, HJ
    Chan, BYP
    Tolleri, L
    Hatfield, GW
    Baldi, P
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (23) : 19937 - 19944
  • [10] Statistical issues with microarrays: processing and analysis
    Nadon, R
    Shoemaker, J
    [J]. TRENDS IN GENETICS, 2002, 18 (05) : 265 - 271
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