Liver development and regeneration: From laboratory study to clinical therapy

被引：49

作者：

Hata, Shoji ^{[1
]}

Namae, Misako ^{[1
]}

Nishina, Hiroshi ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ, Med Res Inst, Dept Dev & Regenerat Biol, Bunkyo Ku, Tokyo 1138510, Japan

来源：

DEVELOPMENT GROWTH & DIFFERENTIATION | 2007年 / 49卷 / 02期

关键词：

cell therapy; knockout mice; liver development; liver regeneration; medaka;

D O I：

10.1111/j.1440-169x.2007.00910.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The liver has an unusual capacity to regenerate after a loss of mass and function caused by surgical resection or toxic liver injury. Over the last 10 years there have been major advances in our understanding of the molecular and cellular mechanisms underlying liver development and regeneration. The numerous factors crucial to these phenomena have been identified mainly by using knockout mice. Forward-genetics studies using zebrafish and medaka have also generated many mutants with liver disorders or defects in liver formation. Our goal is to translate knowledge gained from laboratory work and animal models into novel therapies for human liver diseases. Exciting progress has been achieved using human partial liver transplantation and autologous cell therapy.

引用

页码：163 / 170

页数：8

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