Glucose biosensor based on immobilization of glucose oxidase in platinum nanoparticles/graphene/chitosan nanocomposite film

被引：369

作者：

Wu, Hong ^{[1
]}

Wang, Jun ^{[1
]}

Kang, Xinhuang ^{[1
]}

Wang, Chongmin ^{[1
]}

Wang, Donghai ^{[1
]}

Liu, Jun ^{[1
]}

Aksay, Ilhan A. ^{[2
]}

Lin, Yuehe ^{[1
]}

机构：

[1] Pacific NW Natl Lab, Richland, WA 99352 USA

[2] Princeton Univ, Dept Chem Engn, Princeton, NJ 08544 USA

来源：

TALANTA | 2009年 / 80卷 / 01期

关键词：

Graphene; Platinum nanoparticles; Nanocomposite; Biosensor; Glucose; FUNCTIONALIZED GRAPHENE; CARBON NANOTUBES; GRAPHITE; SHEETS; SENSOR;

D O I：

10.1016/j.talanta.2009.06.054

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The bionanocomposite film consisting of glucose oxidase/Pt/functional graphene sheets/chitosan (GOD/Pt/FGS/chitosan) for glucose sensing is described. With the electrocatalytic synergy of FGS and Pt nanoparticles to hydrogen peroxide, a sensitive biosensor with a detection limit of 0.6 mu M glucose was achieved. The biosensor also has good reproducibility, long-term stability and negligible interfering signals from ascorbic acid and uric acid comparing with the response to glucose. The large surface area and good electrical conductivity of graphene suggests that graphene is a potential candidate as a sensor material. The hybrid nanocomposite glucose sensor provides new opportunity for clinical diagnosis and point-of-care applications. (C) 2009 Published by Elsevier B.V.

引用

收藏

页码：403 / 406

页数：4

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