CD26/Dipeptidyl Peptidase IV and Its Multiple Biological Functions

被引：18
作者：
Pan, Kelsey [1 ]
Ohnuma, Kei [2 ]
Morimoto, Chikao [2 ]
Dang, Nam H. [3 ]
机构：
[1] Univ Florida, Internal Med, Gainesville, FL 32611 USA
[2] Juntendo Univ, Dept Therapy Dev & Innovat Immune Disorders & Can, Tokyo, Japan
[3] Univ Florida, Oncol, Gainesville, FL USA
来源：
CUREUS JOURNAL OF MEDICAL SCIENCE | 2021年 / 13卷 / 02期
关键词：
cd26; dipeptidyl peptidase iv; cancer; diabetes; immunology; infectious disease; covid; TOPOISOMERASE-II-ALPHA; VERSUS-HOST-DISEASE; T-CELL ACTIVATION; MONOCLONAL-ANTIBODY; SERUM CD26; IN-VITRO; EXPRESSION; CANCER; MARKER; 1F7;
D O I：
10.7759/cureus.13495
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
CD26/Dipeptidyl peptidase IV (DPPIV) is a cell surface glycoprotein with numerous roles including glucose metabolism, immunomodulation, and tumorigenesis. CD26/DPPIV is well recognized in diabetes, with DPPIV inhibitors being a class of oral hypoglycemic drugs called gliptins that are commonly used to treat type two diabetes mellitus. Recent work also indicated a potential role for CD26 in infectious diseases, including COVID-19, and immune-mediated disorders such as rheumatoid arthritis, inflammatory bowel disease, and graft-versus-host disease. In cancer, CD26/DPPIV expression has been characterized in numerous tumors such as hematologic malignancies, malignant pleural mesothelioma (MPM), renal cell carcinoma (RCC), hepatocellular carcinoma (HCC), gastrointestinal stromal tumor (GIST), and prostate, lung, colorectal, and ovarian (PLCO) cancer. Hence, CD26 has been frequently studied as a tumor biomarker and therapeutic target. CD26/DPPIV-targeted therapies have been evaluated in various cancers, including the use of anti-CD26 monoclonal antibodies as anticancer treatment in selected neoplasms. This review highlights our current understanding of the role of CD26 in cancer, diabetes, immune-mediated diseases, and infectious diseases. Enhanced understanding of CD26 biology and function may lead to novel therapeutic approaches in multiple human diseases.
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页数：8
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