A novel magnetic resonance contrast agent for detection of hepatic segmental function

被引：2
|
作者：
Qu, Botao [3 ]
Zhang, Xiaomin [3 ]
Wang, Zhenjun [3 ]
Liu, Yi [2 ]
Zhang, Huanhu [4 ]
Zhang, Ruiping [1 ,3 ]
机构：
[1] Shanxi Med Univ, DaYi Hosp, Imaging Dept, Taiyuan 030032, Shanxi, Peoples R China
[2] China Med Univ, Hosp 1, Dept Radiol, Shenyang 110001, Liaoning, Peoples R China
[3] Shanxi Med Univ, Dept Biochem & Mol Biol, Sch Basic Med Sci, Taiyuan 030001, Shanxi, Peoples R China
[4] Shanxi Prov Canc Hosp, Taiyuan 030001, Shanxi, Peoples R China
来源：
MATERIALS LETTERS | 2019年 / 254卷
基金：
中国国家自然科学基金; 山西省青年科学基金;
关键词：
Asialoglycoprotein receptor; Hepatocytes; Liver function; Superparamagnetic nanoparticles; Diagnosis; Liver lesions; LIVER-FUNCTION; IN-VIVO; METASTASES; PHASE;
D O I：
10.1016/j.matlet.2019.07.115
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Aiming at the problems in the detection of liver reserve function, asialoglycoprotein receptor (ASGPR) on the surface of hepatocytes was used as a target, and carboxylated PEG2000 as a ligand was selected to mediate the endocytosis of superparamagnetic nanoparticles in hepatocytes for the detection of liver function. This study provides more abundant imaging basis for the diagnosis and treatment of liver lesions, and then explores a new index for the selection, prognosis and efficacy evaluation of individualized treatment of liver lesions, which provides a preliminary experimental basis for individualized treatment of liver lesions. (C) 2019 Elsevier B.V. All rights reserved.
引用
收藏
页码：452 / 456
页数：5
相关论文
共 50 条
  • [41] A Novel Biomimetic Nanoprobe as a Photoacoustic Contrast Agent
    Huang, Xin
    Shen, Ao
    Peng, Rui
    Chen, Sheng
    Lin, Shitao
    Ding, Shangwei
    Li, Huan
    Zhou, Dazhi
    FRONTIERS IN CHEMISTRY, 2021, 9
  • [42] Detection of Hepatic Hypovascular Metastases: 3D Gradient Echo MRI Using a Hepatobiliary Contrast Agent
    Choi, Jin-Young
    Choi, Jin-Sub
    Kim, Myeong-Jin
    Lim, Joon Seok
    Park, Mi Suk
    Kim, Joo Hee
    Chung, Yong Eun
    JOURNAL OF MAGNETIC RESONANCE IMAGING, 2010, 31 (03) : 571 - 578
  • [43] Magnetic Nanobeads as Potential Contrast Agents for Magnetic Resonance Imaging
    Pablico-Lansigan, Michele H.
    Hickling, William J.
    Japp, Emily A.
    Rodriguez, Olga C.
    Ghosh, Anup
    Albanese, Chris
    Nishida, Maki
    Van Keuren, Edward
    Fricke, Stanley
    Dollahon, Norman
    Stoll, Sarah L.
    ACS NANO, 2013, 7 (10) : 9040 - 9048
  • [44] Contrast Enhanced Magnetic Resonance Imaging in Sacroiliitis
    Tosun, Ozgur
    Tangal, Gulden Saglamer
    Cay, Nurdan
    Maras, Yuksel
    Ercan, Karabekir
    Arslan, Halil
    IRANIAN JOURNAL OF RADIOLOGY, 2017, 14 (01)
  • [45] Magnetoliposomes as magnetic resonance imaging contrast agents
    Soenen, Stefaan J.
    Vande Velde, Greetje
    Ketkar-Atre, Ashwini
    Himmelreich, Uwe
    De Cuyper, Marcel
    WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 2011, 3 (02) : 197 - 211
  • [46] Smart Contrast Agents for Magnetic Resonance Imaging
    Bonnet, Celia S.
    Toth, Eva
    CHIMIA, 2016, 70 (1-2) : 102 - 108
  • [47] The Future of Magnetic Resonance Imaging Contrast Agents
    Minton, Laura E.
    Pandit, Renu
    Willoughby, W. R.
    Porter, Kristin K.
    APPLIED RADIOLOGY, 2022, 51 (01) : 7 - 11
  • [48] Cardiovascular magnetic resonance phase contrast imaging
    Nayak, Krishna S.
    Nielsen, Jon-Fredrik
    Bernstein, Matt A.
    Markl, Michael
    Gatehouse, Peter D.
    Botnar, Rene M.
    Saloner, David
    Lorenz, Christine
    Wen, Han
    Hu, Bob S.
    Epstein, Frederick H.
    Oshinski, John N.
    Raman, Subha V.
    JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 2015, 17
  • [49] Combined magnetic resonance spectroscopy and dynamic contrast-enhanced imaging for prostate cancer detection
    Perdona, Sisto
    Di Lorenzo, Giuseppe
    Autorino, Riccardo
    Buonerba, Carlo
    De Sio, Marco
    Setola, Sergio Venanzio
    Fusco, Roberta
    Ronza, Francesco Michele
    Caraglia, Michele
    Ferro, Matteo
    Petrillo, Antonella
    UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, 2013, 31 (06) : 761 - 765
  • [50] Intracellular enhancement technique for gadoxetic acid-enhanced hepatobiliary-phase magnetic resonance imaging: evaluation of hepatic function
    Fonseca, Dara
    Nakamura, Yuko
    Higaki, Toru
    Maeda, Shogo
    Nishihara, Takashi
    Bito, Yoshitaka
    Takizawa, Masahiro
    Kondo, Shota
    Higashino, Ryo
    Morishita, Shintaro
    Akiyama, Yuji
    Fukuma, Shingo
    Kawaoka, Tomokazu
    Tsuge, Masataka
    Oka, Shiro
    Awai, Kazuo
    ABDOMINAL RADIOLOGY, 2025,
12345