A novel magnetic resonance contrast agent for detection of hepatic segmental function

被引：2
|
作者：
Qu, Botao [3 ]
Zhang, Xiaomin [3 ]
Wang, Zhenjun [3 ]
Liu, Yi [2 ]
Zhang, Huanhu [4 ]
Zhang, Ruiping [1 ,3 ]
机构：
[1] Shanxi Med Univ, DaYi Hosp, Imaging Dept, Taiyuan 030032, Shanxi, Peoples R China
[2] China Med Univ, Hosp 1, Dept Radiol, Shenyang 110001, Liaoning, Peoples R China
[3] Shanxi Med Univ, Dept Biochem & Mol Biol, Sch Basic Med Sci, Taiyuan 030001, Shanxi, Peoples R China
[4] Shanxi Prov Canc Hosp, Taiyuan 030001, Shanxi, Peoples R China
来源：
MATERIALS LETTERS | 2019年 / 254卷
基金：
中国国家自然科学基金; 山西省青年科学基金;
关键词：
Asialoglycoprotein receptor; Hepatocytes; Liver function; Superparamagnetic nanoparticles; Diagnosis; Liver lesions; LIVER-FUNCTION; IN-VIVO; METASTASES; PHASE;
D O I：
10.1016/j.matlet.2019.07.115
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Aiming at the problems in the detection of liver reserve function, asialoglycoprotein receptor (ASGPR) on the surface of hepatocytes was used as a target, and carboxylated PEG2000 as a ligand was selected to mediate the endocytosis of superparamagnetic nanoparticles in hepatocytes for the detection of liver function. This study provides more abundant imaging basis for the diagnosis and treatment of liver lesions, and then explores a new index for the selection, prognosis and efficacy evaluation of individualized treatment of liver lesions, which provides a preliminary experimental basis for individualized treatment of liver lesions. (C) 2019 Elsevier B.V. All rights reserved.
引用
收藏
页码：452 / 456
页数：5
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