Hepatitis B and C in HIV-infected patients - Prevalence and prognostic value

被引:209
作者
Ockenga, J
Tillmann, HL
Trautwein, C
Stoll, M
Manns, MP
Schmidt, RE
机构
[1] HANNOVER MED SCH,DEPT CLIN IMMUNOL,D-30623 HANNOVER,GERMANY
[2] HANNOVER MED SCH,DEPT GASTROENTEROL & HEPATOL,D-30623 HANNOVER,GERMANY
关键词
hepatitis; hepatitis B virus; hepatitis C virus; human immunodeficiency virus; prognosis; replication;
D O I
10.1016/S0168-8278(97)80274-7
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background/Aims: There is only limited information on the prevalence and influence of coinfection with either hepatitis B or C on the clinical course in patients infected with the human immunodeficiency, virus (HIV). Methods: Follow-up was available in 232 HIV-infected patients (age 37+/-8 years, CD4 count 167+/-167 mu l; 46% had AIDS). Samples were investigated for markers of HBV and HCV infection (HBsAg, HBeAg, HBV-DNA, Anti-HBs, anti-HBc, anti-HCV, HCV-RNA). Results: 60/232 patients (23%) were anti-HCV positive, 78% of these sera were positive for HCV-RNA. 22/232 patients (9%) suffered from chronic HBV infection (HBsAg positive), 18/22 (82%) of these sera had detectable HBeAg and 19/22 (86%) HBV-DNA. Presence of HCV-RNA, HBeAg and amount of HBV-DNA were related to the degree of immunodeficiency. In contrast to the control group without HBV or HCV infection, patients infected with HIV and either HBV or HCV showed a direct correlation between a reduction in CD4 counts and decreased cholinesterase activity. In patients with AIDS, coinfection with HBV or HCV was associated with a reduced survival compared to controls (HBV: 212 days, 95%CI, 106-317; HCV: 267, 95%CI, 112-396; controls: 439 days, 95% CI, 364-513). Conclusions: Coinfection of HIV and HBV or HCV is frequently observed. Our results suggest that with prolonged survival of HIV-infected patients, coinfection with either HBV or HCV correlates with a reduced survival rate.
引用
收藏
页码:18 / 24
页数:7
相关论文
共 41 条
[1]   EFFICACY OF LAMIVUDINE ON REPLICATION OF HEPATITIS-B VIRUS IN HIV-INFECTED PATIENTS [J].
BENHAMOU, Y ;
DOHIN, E ;
LUNELFABIANI, F ;
POYNARD, T ;
HURAUX, JM ;
KATLAMA, C ;
OPOLON, P ;
GENTILINI, M .
LANCET, 1995, 345 (8946) :396-397
[2]   RECOMBINANT INTERFERON-ALPHA FOR CHRONIC HEPATITIS-C IN PATIENTS POSITIVE FOR ANTIBODY TO HUMAN-IMMUNODEFICIENCY-VIRUS [J].
BOYER, N ;
MARCELLIN, P ;
DEGOTT, C ;
DEGOS, F ;
SAIMOT, AG ;
ERLINGER, S ;
BENHAMOU, JP .
JOURNAL OF INFECTIOUS DISEASES, 1992, 165 (04) :723-726
[3]   RACE, SEX, DRUG-USE, AND PROGRESSION OF HUMAN-IMMUNODEFICIENCY-VIRUS DISEASE [J].
CHAISSON, RE ;
KERULY, JC ;
MOORE, RD .
NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (12) :751-756
[4]   HEPATITIS-B VIRUS AND HEPATITIS-B-RELATED VIRAL-INFECTION IN RENAL-TRANSPLANT RECIPIENTS - A PROSPECTIVE-STUDY OF 90 PATIENTS [J].
DEGOS, F ;
LUGASSY, C ;
DEGOTT, C ;
DEBURE, A ;
CARNOT, F ;
THIERS, V ;
TIOLLAIS, P ;
KREIS, H ;
BRECHOT, C .
GASTROENTEROLOGY, 1988, 94 (01) :151-156
[5]   PROGNOSTIC FACTORS FOR ALL-CAUSE MORTALITY AMONG HEMOPHILIACS INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS [J].
DIAMONDSTONE, LS ;
BLAKLEY, SA ;
RICE, JC ;
CLARK, RA ;
GOEDERT, JJ .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1995, 142 (03) :304-313
[6]  
DORRUCI M, 1992, J INFECT DIS, V172, P1503
[7]   HEPATITIS-B ANTIBODIES IN HIV-INFECTED HOMOSEXUAL MEN ARE ASSOCIATED WITH MORE RAPID PROGRESSION TO AIDS [J].
ESKILD, A ;
MAGNUS, P ;
PETERSEN, G ;
SOHLBERG, C ;
JENSEN, F ;
KITTELSEN, P ;
SKAUG, K .
AIDS, 1992, 6 (06) :571-574
[8]  
EYSTER ME, 1994, BLOOD, V84, P1020
[9]  
GITNICK G, 1994, GASTROENTEROL CLIN N, V23, P515
[10]  
HABER MM, 1995, AM J GASTROENTEROL, V90, P1250