Rhodium(I)-catalyzed addition of phenols to dienes.: A new convergent synthesis of vitamin E

被引：20

作者：

Bienaymé, H ^{[1
]}

Ancel, JE

Meilland, P

Simonato, JP

机构：

[1] Rhone Poulenc Industrialisat, F-69192 St Fons, France

[2] Rhodia Rech, F-69192 St Fons, France

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 18期

关键词：

vitamin E; homogeneous catalysis; rhodium; C-alkylation; phenol;

D O I：

10.1016/S0040-4039(00)00381-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly convergent and atom-economical synthesis of (dl)-[alpha]-tocopherol (vitamin E) is proposed, the realization of which was made possible by the discovery of the regioselective Rh(I)-catalyzed arylation of beta-springene with trimethylhydroquinone. Other phenolic compounds and 2-substituted-1,3-dienes were shown to undergo this transformation. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：3339 / 3343

页数：5

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