Rhodium(I)-catalyzed addition of phenols to dienes.: A new convergent synthesis of vitamin E

被引：19
|
作者：
Bienaymé, H [1 ]
Ancel, JE
Meilland, P
Simonato, JP
机构：
[1] Rhone Poulenc Industrialisat, F-69192 St Fons, France
[2] Rhodia Rech, F-69192 St Fons, France
来源：
TETRAHEDRON LETTERS | 2000年 / 41卷 / 18期
关键词：
vitamin E; homogeneous catalysis; rhodium; C-alkylation; phenol;
D O I：
10.1016/S0040-4039(00)00381-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly convergent and atom-economical synthesis of (dl)-[alpha]-tocopherol (vitamin E) is proposed, the realization of which was made possible by the discovery of the regioselective Rh(I)-catalyzed arylation of beta-springene with trimethylhydroquinone. Other phenolic compounds and 2-substituted-1,3-dienes were shown to undergo this transformation. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：3339 / 3343
页数：5
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