Is the action spectrum for the UV-induced production of previtamin D3 in human skin correct?

被引：75

作者：

Norval, Mary ^{[1
]}

Bjorn, Lars Olof ^{[2
,3
]}

de Gruijl, Frank R. ^{[4
]}

机构：

[1] Univ Edinburgh, Sch Med, Edinburgh EH8 9AG, Midlothian, Scotland

[2] Lund Univ, Dept Cell & Organism Biol, Lund, Sweden

[3] S China Normal Univ, Sch Life Sci, Key Lab Ecol & Environm Sci Guangdong Higher Educ, Guangzhou, Guangdong, Peoples R China

[4] Leiden Univ, Med Ctr, Dept Dermatol, Leiden, Netherlands

来源：

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES | 2010年 / 9卷 / 01期

关键词：

VITAMIN-D; 1-ALPHA; 25-DIHYDROXYVITAMIN D-3; CUTANEOUS PRODUCTION; ABSORPTION-SPECTRA; INDUCED CONVERSION; SUNLIGHT; ULTRAVIOLET; EXPOSURE; 7-DEHYDROCHOLESTEROL; PHOTOSYNTHESIS;

D O I：

10.1039/b9pp00012g

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The universally recognised action spectrum for the UV-induced conversion of 7-dehydrocholesterol to previtamin D-3 in human skin was published in 1982, and indicates a maximum at about 297 nm with essentially no production above 315 nm. This work represents a milestone in research on vitamin D, but limitations in the original data should be recognised. Various findings have arisen in recent years which cast doubts on the accuracy of the action spectrum and its application for spectral weighting in calculations of effective UV doses. In conclusion, the construction of an entirely new computational model to predict previtamin D levels is recommended.

引用

页码：11 / 17

页数：7

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