DNA damage induced by coexposure to PAHs and light

被引：68

作者：

Toyooka, Tatsushi ^{[1
]}

Ibuki, Yuko ^{[1
]}

机构：

[1] Univ Shizuoka, Grad Sch Nutr & Environm Sci, Radiat Biol Lab, Shizuoka 4228526, Japan

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2007年 / 23卷 / 02期

关键词：

polycyclic aromatic hydrocarbons; phototoxicity; ultraviolet; DNA damage; photomutagenicity; photocarcinogenicity;

D O I：

10.1016/j.etap.2006.09.002

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Polycyclic aromatic hydrocarbons (PAHs) are widely distributed in the environment as pollutants in air, water and soil, and some are carcinogenic, being associated with various types of cancer. A majority of the research concerning the biological effects of PAHs has focused on the metabolic activation and DNA adducts leading to mutation and transformation. Although the role of the PAHs as photo sensitizers has received much less attention, investigators have shown that PAHs excited by sunlight induced significant cytotoxicity and several kinds of DNA damage. Some PAHs were recently proved to be photommagenic. In this review, we discuss the influence of PAHs in combination with sunlight focusing on the phototoxicity and cellular DNA damage produced. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：256 / 263

页数：8

共 64 条

[1] The effects of near ultraviolet radiation on the toxic effects of polycyclic aromatic hydrocarbons in animals and plants: A review [J].

Arfsten, DP ;

Schaeffer, DJ ;

Mulveny, DC .

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 1996, 33 (01) :1-24

[2] MUTATION OF CHINESE-HAMSTER CELLS BY NEAR-UV ACTIVATION OF PROMUTAGENS [J].

BARNHART, BJ ;

COX, SH .

MUTATION RESEARCH, 1980, 72 (01) :135-142

[3]

Besaratinia A, 2003, CANCER RES, V63, P8708

[4] Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air [J].

Boström, CE ;

Gerde, P ;

Hanberg, A ;

Jernström, B ;

Johansson, C ;

Kyrklund, T ;

Rannug, A ;

Törnqvist, M ;

Victorin, K ;

Westerholm, R .

ENVIRONMENTAL HEALTH PERSPECTIVES, 2002, 110 :451-488

[5] PHOTOCHEMICAL COUPLING OF BENZO[ALPHA)PYRENE WITH 1-METHYLCYTOSINE - PHOTOENHANCEMENT OF CARCINOGENICITY [J].

CAVALIERI, E ;

CALVIN, M .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1971, 14 (05) :641-+

[6] SINGLET OXYGEN INDUCED SINGLE-STRAND BREAKS IN PLASMID-PBR322 DNA - THE ENHANCING EFFECT OF THIOLS [J].

DEVASAGAYAM, TPA ;

DI MASCIO, P ;

KAISER, S ;

SIES, H .

BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1088 (03) :409-412

[7] UVA light-induced DNA cleavage by isomeric methylbenz[a]anthracenes [J].

Dong, S ;

Fu, PP ;

Shirsat, RN ;

Hwang, HM ;

Leszczynski, J ;

Yu, H .

CHEMICAL RESEARCH IN TOXICOLOGY, 2002, 15 (03) :400-407

[8] UVA-induced DNA single-strand cleavage by 1-hydroxypyrene and formation of covalent adducts between DNA and 1-hydroxypyrene [J].

Dong, SM ;

Hwang, HM ;

Shi, XC ;

Holloway, L ;

Yu, HT .

CHEMICAL RESEARCH IN TOXICOLOGY, 2000, 13 (07) :585-593

[9]

DONIACH I., 1940, AMER JOUR CANCER, V39, P234

[10]

Du HY, 2003, INT J ONCOL, V23, P1401

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