Methicillin-Resistant Staphylococcus aureus (MRSA)-Active Metabolites from Platanus occidentalis (American Sycamore)

被引：40

作者：

Ibrahim, Mohamed A. ^{[1
]}

Mansoor, Arsala A. ^{[1
]}

Gross, Amanda ^{[1
]}

Ashfaq, M. Khalid ^{[4
]}

Jacob, Melissa ^{[4
]}

Khan, Shabana I. ^{[1
,4
]}

Hamann, Mark T. ^{[1
,2
,3
,5
,6
]}

机构：

[1] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, University, MS 38677 USA

[2] Univ Mississippi, Sch Pharm, Dept Pharmacol, University, MS 38677 USA

[3] Univ Mississippi, Sch Pharm, Dept Chem, University, MS 38677 USA

[4] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA

[5] Triton Biopharma LLC, Oxford, MS 38655 USA

[6] Univ Mississippi, Sch Pharm, Dept Biochem, University, MS 38677 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 12期

关键词：

LAURUS-NOBILIS; MRSA; BUDS;

D O I：

10.1021/np900499q

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

One known and three new potent, selective, and nontoxic anti-MRSA metabolites, kaempferol 3-O-alpha-L-(2 '',3 ''-di-E-p-coumaroyl)rhamnoside (1) (IC50 2.0 mu g/mL), kaempferol 3-O-alpha-L-(2 ''-E-p-coumaroyl-3 ''-Z-p-coumaroyl)rhamnoside (2) (IC50 0.8 mu g/mL), kaempferol 3-O-alpha-L-(2 ''-Z-p-coumaroyl-3 ''-E-p-coumaroyl)rhamnoside (3) (IC50 0.7 mu g/mL), and kaempferol 3-O-alpha-L-(2 '',3 ''-di-Z-p-coumaroyl)rhamnoside (4) (IC50 0.4 mu g/mL), were isolated from the leaves of the common American sycamore, Platanus occidentalis. Compounds 2-4 are new. Due to the unusual selectivity, potency, and safety of the pure compounds and the semipure glycoside mixture against MRSA, it is clear that this represents a viable class of inhibitors to prevent growth of MRSA on surfaces and systemically.

引用

页码：2141 / 2144

页数：4

共 26 条

[1] Reduced glycopeptide susceptibility in methicillin-resistant Staphylococcus aureus (MRSA) [J].